Robotic radical hysterectomy following neoadjuvant chemotherapy in FIGO stage IIIB cervical cancer: A case report

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Abstract

Background: The management of advanced cervical cancer is challenging. The administration of neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has proved to be safe in selected cases. Nevertheless, data on the use of minimally invasive surgery is lacking with this clinical application. Methods: A 31year-old woman was diagnosed with a FIGO stage IIIB squamous cell cervical carcinoma. During multidisciplinary consultation it was decided that she should receive NACT, followed by robotic hysterectomy. Results: After three cycles of TIP (paclitaxel, ifosfamide and cisplatin), the patient achieved a complete clinical and radiological response. She underwent robotic type III/C2 radical hysterectomy with bilateral salpingo-oophorectomy and bilateral systematic pelvic lymphadenectomy. No complications were recorded. The complete response was confirmed at pathological examination. Two additional cycles of adjuvant chemotherapy were administered, and the patient is currently without evidence of disease at 18months of follow-up. Conclusions: In selected patients, robotics is a viable option to accomplish radical hysterectomy, including cases of advanced cervical cancer. Further experiences are needed to confirm our findings.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalInternational Journal of Medical Robotics and Computer Assisted Surgery
Volume10
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Chemotherapy
Robotics
Hysterectomy
Uterine Cervical Neoplasms
Drug Therapy
Ifosfamide
Surgery
Minimally Invasive Surgical Procedures
Ovariectomy
Adjuvant Chemotherapy
Lymph Node Excision
Squamous Cell Carcinoma
Referral and Consultation

Keywords

  • Cervical carcinoma
  • Neoadjuvant chemotherapy
  • Pelvic lymphadenectomy
  • Robot-assisted laparoscopy
  • Robotic surgery

ASJC Scopus subject areas

  • Computer Science Applications
  • Biophysics
  • Surgery

Cite this

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title = "Robotic radical hysterectomy following neoadjuvant chemotherapy in FIGO stage IIIB cervical cancer: A case report",
abstract = "Background: The management of advanced cervical cancer is challenging. The administration of neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has proved to be safe in selected cases. Nevertheless, data on the use of minimally invasive surgery is lacking with this clinical application. Methods: A 31year-old woman was diagnosed with a FIGO stage IIIB squamous cell cervical carcinoma. During multidisciplinary consultation it was decided that she should receive NACT, followed by robotic hysterectomy. Results: After three cycles of TIP (paclitaxel, ifosfamide and cisplatin), the patient achieved a complete clinical and radiological response. She underwent robotic type III/C2 radical hysterectomy with bilateral salpingo-oophorectomy and bilateral systematic pelvic lymphadenectomy. No complications were recorded. The complete response was confirmed at pathological examination. Two additional cycles of adjuvant chemotherapy were administered, and the patient is currently without evidence of disease at 18months of follow-up. Conclusions: In selected patients, robotics is a viable option to accomplish radical hysterectomy, including cases of advanced cervical cancer. Further experiences are needed to confirm our findings.",
keywords = "Cervical carcinoma, Neoadjuvant chemotherapy, Pelvic lymphadenectomy, Robot-assisted laparoscopy, Robotic surgery",
author = "Gabriele Siesto and Domenico Vitobello",
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AU - Siesto, Gabriele

AU - Vitobello, Domenico

PY - 2014

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N2 - Background: The management of advanced cervical cancer is challenging. The administration of neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has proved to be safe in selected cases. Nevertheless, data on the use of minimally invasive surgery is lacking with this clinical application. Methods: A 31year-old woman was diagnosed with a FIGO stage IIIB squamous cell cervical carcinoma. During multidisciplinary consultation it was decided that she should receive NACT, followed by robotic hysterectomy. Results: After three cycles of TIP (paclitaxel, ifosfamide and cisplatin), the patient achieved a complete clinical and radiological response. She underwent robotic type III/C2 radical hysterectomy with bilateral salpingo-oophorectomy and bilateral systematic pelvic lymphadenectomy. No complications were recorded. The complete response was confirmed at pathological examination. Two additional cycles of adjuvant chemotherapy were administered, and the patient is currently without evidence of disease at 18months of follow-up. Conclusions: In selected patients, robotics is a viable option to accomplish radical hysterectomy, including cases of advanced cervical cancer. Further experiences are needed to confirm our findings.

AB - Background: The management of advanced cervical cancer is challenging. The administration of neoadjuvant chemotherapy (NACT) followed by radical hysterectomy has proved to be safe in selected cases. Nevertheless, data on the use of minimally invasive surgery is lacking with this clinical application. Methods: A 31year-old woman was diagnosed with a FIGO stage IIIB squamous cell cervical carcinoma. During multidisciplinary consultation it was decided that she should receive NACT, followed by robotic hysterectomy. Results: After three cycles of TIP (paclitaxel, ifosfamide and cisplatin), the patient achieved a complete clinical and radiological response. She underwent robotic type III/C2 radical hysterectomy with bilateral salpingo-oophorectomy and bilateral systematic pelvic lymphadenectomy. No complications were recorded. The complete response was confirmed at pathological examination. Two additional cycles of adjuvant chemotherapy were administered, and the patient is currently without evidence of disease at 18months of follow-up. Conclusions: In selected patients, robotics is a viable option to accomplish radical hysterectomy, including cases of advanced cervical cancer. Further experiences are needed to confirm our findings.

KW - Cervical carcinoma

KW - Neoadjuvant chemotherapy

KW - Pelvic lymphadenectomy

KW - Robot-assisted laparoscopy

KW - Robotic surgery

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