Robotic radiosurgery in pancreatic cancer: A systematic review

Milly Buwenge, Francesco Cellini, Nicola Silvestris, Savino Cilla, Francesco Deodato, Gabriella Macchia, Gian C. Mattiucci, Vincenzo Valentini, Alessio G. Morganti

Research output: Contribution to journalArticle


AIM: to present a systematic review of techniques and clinical results. METHODS: A systematic review of published literature was performed. Only studies reporting patient outcome after radiosurgery (single fraction) delivered with robotic devices [i.e. , robotic radiosurgery (RRS)] have been analyzed. RESULTS: A total of 96 patients from 5 studies were included. The studies are characterized by small series and different methods in terms of dose, target definition, combination with chemotherapy and/or standard fractionated radiotherapy and evaluation modalities. Preliminary results are positive in terms of tumor response (ORR = 56%) and local control of the tumor (crude rate of local progressions: 19.5%). Results for median overall survival (11.4 mo) seem comparable with the ones of prolonged chemoradiation (range: 8.6-13.0 mo). However, gastrointestinal toxicity seems to be the main limitation of RRS, especially at the duodenal level. CONCLUSION: RRS allows for local treatment in a shortened time (1 fraction) compared to traditional treatments (about 1 mo), providing the possibility for an easy integration with systemic therapies. Preliminary results did not show any outcome differences compared to standard chemoradiation. Thus, further efforts to reduce gastrointestinal toxicity are strongly needed.

Original languageEnglish
Pages (from-to)9420-9429
Number of pages10
JournalWorld Journal of Gastroenterology
Issue number31
Publication statusPublished - Aug 21 2015


  • Pancreas
  • Pancreatic neoplasms
  • Radiosurgery
  • Review
  • Robotic
  • Stereotactic radiotherapy
  • Systematic review

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Buwenge, M., Cellini, F., Silvestris, N., Cilla, S., Deodato, F., Macchia, G., Mattiucci, G. C., Valentini, V., & Morganti, A. G. (2015). Robotic radiosurgery in pancreatic cancer: A systematic review. World Journal of Gastroenterology, 21(31), 9420-9429.