Robotic Versus Open Radical Hysterectomy in Women With Locally Advanced Cervical Cancer After Neoadjuvant Chemotherapy: A Single-institution Experience of Surgical and Oncologic Outcomes

Vanna Zanagnolo, Lucas Minig, Jose Miguel Cárdenas-Rebollo, Maria Teresa Achilarre, Annalisa Garbi, Maria Guadalupe Patrono, Nicoletta Colombo, Angelo Maggioni

Research output: Contribution to journalArticle

Abstract

Study Objective: To compare the surgical and oncologic outcomes of robotic radical hysterectomy (RRH) versus laparotomy in women with locally advanced cervical cancer (LACC) after neoadjuvant chemotherapy (NACT). Setting: Oncology referral center. Design: A retrospective comparative observational study was performed in 30 patients with LACC Fédération Internationale de Gynécologie et d'Obstétrique stage IB2-IIB who underwent RRH after NACT between February 2008 and December 2014. This group was compared with a cohort of 44 patients with similar characteristics who underwent abdominal radical hysterectomy after NACT (Canadian Task Force classification II2). Patients: Patients with LACC FIGO stage IB2-IIB. Interventions: A retrospective comparative observational study. Measurements and Main Results: The mean (standard deviation [SD]) operative time was significantly longer in the robotic group (307.8 minutes [40.2] vs 233.7 minutes [61.9], p ≤ .001). On the contrary, the mean (SD) estimated blood loss was significantly lower in the robotic group (111.0 mL [69.6] vs 286.9 mL [159.1], p ≤ .001), and length of stay was significantly shorter (4.1 [2.4] days vs 5.8 days [3.3], p = .015). The incidence of intraoperative and early and late complications was not statistically significantly different between the 2 groups. The mean (SD) follow-up of patients was 35.6 months (28.4) and 43.7 months (23.2) in the open and robotic groups, respectively (p = .137). The disease recurrence rate (27.2% vs 20%) was similar between the 2 groups; sites and types of recurrences were also similar. Kaplan-Meier survival analysis for median progression-free survival and median overall survival were not statistically different comparing cohorts by surgery type. Conclusions: RRH after NACT in women with LACC is associated with similar perioperative and oncologic outcomes to open procedure. These results require further investigation to establish a more robust conclusion.

Original languageEnglish
JournalJournal of Minimally Invasive Gynecology
DOIs
Publication statusAccepted/In press - Mar 19 2016

Keywords

  • Abdominal radical hysterectomy
  • Complications
  • Locally advanced cervical cancer
  • Neoadjuvant chemotherapy
  • Robotic radical hysterectomy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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