Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In preclinical rodent models of autism spectrum disorders (ASD), the study of ultrasonic vocalizations (USVs) has provided the opportunity to evaluate in ethologically appropriate contexts a behavioral domain (social communication) that is relevant to the core diagnostic of the ASD symptomatology. In this chapter, we review a selection of data concerning USVs in mouse models of ASD both in the neonatal phase and in adulthood in different experimental contexts and with the emphasis on the spectrographic analyses to assess the role of vocalizations in these models. Abnormalities have been evidenced both quantitatively (calling rate) and qualitatively (range of the vocal repertoire). We also highlight several promises and a few caveats in the use of USVs for behavioral phenotyping of ASD mouse models, with some suggestions to maximize the translational potential of these studies.

Original languageEnglish
Title of host publicationHandbook of Behavioral Neuroscience
EditorsStefan M. Brudzynski
PublisherElsevier B.V.
Pages445-456
Number of pages12
ISBN (Print)9780128096000
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameHandbook of Behavioral Neuroscience
Volume25
ISSN (Print)1569-7339

Fingerprint

Rodentia
Animal Models
Ultrasonics
Communication
Autism Spectrum Disorder

Keywords

  • Courtship male mouse vocalizations
  • Maternal potentiation
  • Mouse models of neurodevelopmental disorders
  • Spectrographic analysis of USVs
  • Ultrasonic calls

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Scattoni, M. L., Michetti, C., & Ricceri, L. (2018). Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder. In S. M. Brudzynski (Ed.), Handbook of Behavioral Neuroscience (pp. 445-456). (Handbook of Behavioral Neuroscience; Vol. 25). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-809600-0.00042-1

Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder. / Scattoni, Maria Luisa; Michetti, Caterina; Ricceri, Laura.

Handbook of Behavioral Neuroscience. ed. / Stefan M. Brudzynski. Elsevier B.V., 2018. p. 445-456 (Handbook of Behavioral Neuroscience; Vol. 25).

Research output: Chapter in Book/Report/Conference proceedingChapter

Scattoni, ML, Michetti, C & Ricceri, L 2018, Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder. in SM Brudzynski (ed.), Handbook of Behavioral Neuroscience. Handbook of Behavioral Neuroscience, vol. 25, Elsevier B.V., pp. 445-456. https://doi.org/10.1016/B978-0-12-809600-0.00042-1
Scattoni ML, Michetti C, Ricceri L. Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder. In Brudzynski SM, editor, Handbook of Behavioral Neuroscience. Elsevier B.V. 2018. p. 445-456. (Handbook of Behavioral Neuroscience). https://doi.org/10.1016/B978-0-12-809600-0.00042-1
Scattoni, Maria Luisa ; Michetti, Caterina ; Ricceri, Laura. / Rodent Vocalization Studies in Animal Models of the Autism Spectrum Disorder. Handbook of Behavioral Neuroscience. editor / Stefan M. Brudzynski. Elsevier B.V., 2018. pp. 445-456 (Handbook of Behavioral Neuroscience).
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