Abstract
The demonstration that type 2 transglutaminase (TG2) can incorporate polyamine into the E7 oncoprotein of human papillomavirus (HPV) type 18 has led to the hypothesis that TG2 can have a role in the host cellular response to HPV infection. The aim of this study was to investigate whether HPV-related pathology, in infected human cervical epithelium, was associated with modulation of TG2 expression. Normal controls and HPV-infected cervical biopsies were analyzed for the expression of TG2, and the findings were compared with lesion grade. The correlation between TG2 expression and p16, a marker for HPV-induced dysplasia, and the retinoblastoma protein (Rb), a target of the E7 protein of HPV, was also investigated. Results obtained showed that TG2 was absent in normal squamous mucosa, whereas it was present in 100% CIN I lesions. Low-grade lesions showed significantly higher TG2 expression than high-grade lesions (P
| Original language | English |
|---|---|
| Pages (from-to) | 855-865 |
| Number of pages | 11 |
| Journal | Modern Pathology |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2011 |
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Keywords
- cervical intraepithelial neoplasia
- HPV
- p16
- pRb
- TG2
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Role and predictive strength of transglutaminase type 2 expression in premalignant lesions of the cervix. / Del Nonno, Franca; Pisani, Giuseppe; Visca, Paolo; Signore, Fabrizio; Grillo, Lucia Rosalba; Baiocchini, Andrea; Garbuglia, Anna Rosa; Sepe, Sara; Piacentini, Mauro; Falasca, Laura.
In: Modern Pathology, Vol. 24, No. 6, 06.2011, p. 855-865.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role and predictive strength of transglutaminase type 2 expression in premalignant lesions of the cervix
AU - Del Nonno, Franca
AU - Pisani, Giuseppe
AU - Visca, Paolo
AU - Signore, Fabrizio
AU - Grillo, Lucia Rosalba
AU - Baiocchini, Andrea
AU - Garbuglia, Anna Rosa
AU - Sepe, Sara
AU - Piacentini, Mauro
AU - Falasca, Laura
PY - 2011/6
Y1 - 2011/6
N2 - The demonstration that type 2 transglutaminase (TG2) can incorporate polyamine into the E7 oncoprotein of human papillomavirus (HPV) type 18 has led to the hypothesis that TG2 can have a role in the host cellular response to HPV infection. The aim of this study was to investigate whether HPV-related pathology, in infected human cervical epithelium, was associated with modulation of TG2 expression. Normal controls and HPV-infected cervical biopsies were analyzed for the expression of TG2, and the findings were compared with lesion grade. The correlation between TG2 expression and p16, a marker for HPV-induced dysplasia, and the retinoblastoma protein (Rb), a target of the E7 protein of HPV, was also investigated. Results obtained showed that TG2 was absent in normal squamous mucosa, whereas it was present in 100% CIN I lesions. Low-grade lesions showed significantly higher TG2 expression than high-grade lesions (P
AB - The demonstration that type 2 transglutaminase (TG2) can incorporate polyamine into the E7 oncoprotein of human papillomavirus (HPV) type 18 has led to the hypothesis that TG2 can have a role in the host cellular response to HPV infection. The aim of this study was to investigate whether HPV-related pathology, in infected human cervical epithelium, was associated with modulation of TG2 expression. Normal controls and HPV-infected cervical biopsies were analyzed for the expression of TG2, and the findings were compared with lesion grade. The correlation between TG2 expression and p16, a marker for HPV-induced dysplasia, and the retinoblastoma protein (Rb), a target of the E7 protein of HPV, was also investigated. Results obtained showed that TG2 was absent in normal squamous mucosa, whereas it was present in 100% CIN I lesions. Low-grade lesions showed significantly higher TG2 expression than high-grade lesions (P
KW - cervical intraepithelial neoplasia
KW - HPV
KW - p16
KW - pRb
KW - TG2
UR - http://www.scopus.com/inward/record.url?scp=79957879889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957879889&partnerID=8YFLogxK
U2 - 10.1038/modpathol.2011.40
DO - 10.1038/modpathol.2011.40
M3 - Article
C2 - 21441900
AN - SCOPUS:79957879889
VL - 24
SP - 855
EP - 865
JO - Modern Pathology
JF - Modern Pathology
SN - 0893-3952
IS - 6
ER -