Role and predictive strength of transglutaminase type 2 expression in premalignant lesions of the cervix

Franca Del Nonno, Giuseppe Pisani, Paolo Visca, Fabrizio Signore, Lucia Rosalba Grillo, Andrea Baiocchini, Anna Rosa Garbuglia, Sara Sepe, Mauro Piacentini, Laura Falasca

Research output: Contribution to journalArticle

Abstract

The demonstration that type 2 transglutaminase (TG2) can incorporate polyamine into the E7 oncoprotein of human papillomavirus (HPV) type 18 has led to the hypothesis that TG2 can have a role in the host cellular response to HPV infection. The aim of this study was to investigate whether HPV-related pathology, in infected human cervical epithelium, was associated with modulation of TG2 expression. Normal controls and HPV-infected cervical biopsies were analyzed for the expression of TG2, and the findings were compared with lesion grade. The correlation between TG2 expression and p16, a marker for HPV-induced dysplasia, and the retinoblastoma protein (Rb), a target of the E7 protein of HPV, was also investigated. Results obtained showed that TG2 was absent in normal squamous mucosa, whereas it was present in 100% CIN I lesions. Low-grade lesions showed significantly higher TG2 expression than high-grade lesions (P

Original languageEnglish
Pages (from-to)855-865
Number of pages11
JournalModern Pathology
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2011

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Keywords

  • cervical intraepithelial neoplasia
  • HPV
  • p16
  • pRb
  • TG2

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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