Role and prognostic significance of CD44s expression in colorectal cancer

Paolo Visca, Franca Del Nonno, Claudio Botti, Ferdinando Marandino, Valeria Sebastiani, Ugo Di Tondo, Raffaele Perrone Donnorso, Giorgio Trombetta, Stefania Filippi, Piero Luigi Alo

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to clarify the role and the predictive strength of the adhesion molecule CD44s (standard isoform) in colorectal carcinogenesis. Materials and Methods: CD44s immunohistochemical expression was evaluated in 100 patients with colon adenoma and 100 patients with colon adenocarcinoma and adjacent non-neoplastic mucosa (ANNM). The patients were followed-up for five years. Results: CD44s immunoreactivity was expressed in low-moderate-high-grade dysplasia adenomas and associated with adenocarcinoma (p=0.01), ANNM (p=0.05) and pTNM stage (p=0.00001). Univariate analysis revealed that CD44s expression was associated with overall survival (OS) in carcinomas (p=0.01) and ANNM (p=0.05). Bivariate analysis revealed that CD44s was associated with OS in stages I and II patients (p=0.03). Multivariate analysis revealed that stage (p=0.0001) and CD44s expression (p=0.05) were independent predictors of OS. Conclusion: CD44s is involved in colon carcinogenesis and is associated with aggressive carcinomas. The immunohistochemical expression of CD44s may reveal cells that have lost their adhesion ability and therefore detect carcinomas with high metastatic power.

Original languageEnglish
Pages (from-to)2671-2675
Number of pages5
JournalAnticancer Research
Volume22
Issue number5
Publication statusPublished - Sep 2002

Keywords

  • Carcinogenesis
  • CD44s
  • Colorectal
  • Immunohistochemistry
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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