Role of β-chemokines in allergic diseases

R. Paganelli, A. M. Mazzone, E. Scala, A. Peserico, L. Bertollo, S. Bellegrandi, U. Fagiolo

Research output: Contribution to journalArticle

Abstract

Inflammation represents the key event in the pathogenesis of allergic diseases. Several mediators, produced by immune and non immune cells, are known to play a role in inflammation. Recently chemokines of the C-C (β) family have been identified to possess both histamine-releasing and eosinophil-activating properties. We selected 26 patients affected by chronic urticaria (CU) and compared serum b chemokine levels with those of healthy nonatopic controls and subjects with allergic asthma and/or rhinitis. We further subdivided CU patients according to intradermal (ID) reaction to autologous serum - a test claimed to discriminate a possible autoimmune pathogenesis. 20 CU patients had a positive ID test, and 7 of them turned negative with improvement of symptoms. Serum levels of the chemokines RANTES, MCP-1, and MIP-1a (measured by ELISA) were increased in patients with respiratory allergy but only slightly in CU. However we observed a significant decrease of β chemokines in cases of CU after their ID test turned negative. These findings point to the possible involvement of β chemokines as mediators of allergic inflammation both in respiratory allergy and in urticarial syndromes, where they may exert histamine-releasing activity.

Original languageEnglish
Pages (from-to)153-154
Number of pages2
JournalInternational Journal of Immunopathology and Pharmacology
Volume10
Issue number2 SUPPL.
Publication statusPublished - 1997

Keywords

  • chemokine
  • histamine
  • urticaria

ASJC Scopus subject areas

  • Pharmacology

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    Paganelli, R., Mazzone, A. M., Scala, E., Peserico, A., Bertollo, L., Bellegrandi, S., & Fagiolo, U. (1997). Role of β-chemokines in allergic diseases. International Journal of Immunopathology and Pharmacology, 10(2 SUPPL.), 153-154.