Role of adrenal gland scintigraphy in patients with subclinical hypercortisolism and incidentally discovered adrenal mass

F. Donadio, V. Morelli, A. S. Salcuni, C. Eller-Vainicher, M. Carletto, M. Castellani, L. Dellavedova, A. Scillitani, P. Beck-Peccoz, I. Chiodini

Research output: Contribution to journalArticle

Abstract

Background: The role of adrenal scintigraphy (AS) in the diagnosis of subclinical hypercortisolism (SH) in adrenal incidentaloma (AI) is debated. Aim: To evaluate the possible role of AS in identifying SH in AI patients. Subjects and methods: In the retrospective phase (2000-2004), 102 AI patients [71 females (F)/31 males (M)] referred to our center were reevaluated for SH. In the prospective phase (2005-2006), 42 patients (32F/10M) with suspected SH were evaluated performing AS and biochemical assessment of cortisol secretion. We report data of the prospective phase of the study. In these patients AS was performed at baseline; the difference between the uptake of the affected and the controlateral gland [mean Δ uptake (Mςu)] was calculated. Cortisol secretion was evaluated in 3 different occasions. Patients were considered affected with SH if they presented at least twice 2 of the following criteria: urinary free cortisol >193 nmol/l, cortisol after 1 mg dexamethasone suppression test >83 nmol/l, ACTH levels

Original languageEnglish
Pages (from-to)576-580
Number of pages5
JournalJournal of Endocrinological Investigation
Volume32
Issue number7
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Adenoma
  • Adrenal cortex
  • Adrenal scintigraphy
  • Incidentaloma
  • Subclinical hypercortisolism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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