Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders

Alessandra Minelli, Elisabetta Maffioletti, Claude Robert Cloninger, Chiara Magri, Riccardo Sartori, Marco Bortolomasi, Chiara Congiu, Stefano Bignotti, Matilde Segala, Mario Giacopuzzi, Massimo Gennarelli

Research output: Contribution to journalArticle


Background Anxiety disorders exhibit remarkably high rates of comorbidity with major depressive disorder (MDD). Mood and anxiety disorders are considered stress-related diseases. Genetic variations in the co-chaperone FK506-binding protein 51, FKBP5, which modulates the function of glucocorticoid receptors, have been associated with an increased risk for the development of posttraumatic stress disorder, but data regarding its role in MDD are controversial. The aims of this study were to clarify the role of the FKBP5 gene in depression and anxiety disorders through a case-control study and an association study with personality traits using the Temperament and Character Inventory (TCI) in healthy subjects. Methods Six hundred fifty-seven MDD patients, with or without an anxiety disorder in comorbidity, and 462 healthy volunteers were enrolled in the study. Two hundred fifty-six controls agreed to fill out the TCI. Results The results showed that the T allele of rs1360780 was more frequent among the patients affected by MDD with a comorbidity of anxiety disorders, compared to those without (P

Original languageEnglish
Pages (from-to)1170-1176
Number of pages7
JournalDepression and Anxiety
Issue number12
Publication statusPublished - Dec 2013



  • anxiety
  • FKBP5
  • harm avoidance
  • major depressive disorder
  • temperament & character inventory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Minelli, A., Maffioletti, E., Cloninger, C. R., Magri, C., Sartori, R., Bortolomasi, M., Congiu, C., Bignotti, S., Segala, M., Giacopuzzi, M., & Gennarelli, M. (2013). Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders. Depression and Anxiety, 30(12), 1170-1176.