Role of ANCA in the pathogenesis of Wegener's granulomatosis: A short review

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Abstract

The presence of autoantibodies to neutrophil cytoplasmic proteinase-3, usually reported as c-ANCA, is virtually diagnostic for Wegener's granulomatosis and related conditions. These antibodies are highly associated with active systemic disease, and may be implicated in pathogenesis. In vitro, c-ANCA can induce a-respiratory burst and degranulation of cytokine-primed neutrophils, leading to lysis of cultured endothelial cells. This and other putative pathogenic mechanisms are reviewed.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalMonaldi Archives for Chest Disease - Cardiac Series
Volume49
Issue number4
Publication statusPublished - 1994

Keywords

  • Antineutrophil cytoplasmic antibodies
  • Vasculitis
  • Wegener's granulomatosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine

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