TY - JOUR
T1 - Role of angiotensin II in plasma PAI-1 changes induced by imidapril or candesartan in hypertensive patients with metabolic syndrome
AU - Fogari, Roberto
AU - Zoppi, Annalisa
AU - Mugellini, Amedeo
AU - Maffioli, Pamela
AU - Lazzari, Pierangelo
AU - Derosa, Giuseppe
PY - 2011/12
Y1 - 2011/12
N2 - To evaluate the relationship between plasma plasminogen activator inhibitor-1 (PAI-1) and angiotensin II (Ang II) changes during treatment with imidapril and candesartan in hypertensive patients with metabolic syndrome. A total of 84 hypertensive patients with metabolic syndrome were randomized to imidapril 10 mg or candesartan 16 mg for 16 weeks. At weeks 4 and 8, there was a dose titration to imidapril 20 mg and candesartan 32 mg in nonresponders (systolic blood pressure (SBP) >140 and/or diastolic blood pressure (DBP) >90 mm Hg). We evaluated, at baseline and after 2, 4, 8, 12 and 16 weeks, clinic blood pressure, Ang II and PAI-1 antigen. Both imidapril and candesartan induced a similar SBP/DBP reduction (-19.4/16.8 and-19.5/16.3 mm Hg, respectively, P-1, P-1, P-1 at week 16, P-1, P
AB - To evaluate the relationship between plasma plasminogen activator inhibitor-1 (PAI-1) and angiotensin II (Ang II) changes during treatment with imidapril and candesartan in hypertensive patients with metabolic syndrome. A total of 84 hypertensive patients with metabolic syndrome were randomized to imidapril 10 mg or candesartan 16 mg for 16 weeks. At weeks 4 and 8, there was a dose titration to imidapril 20 mg and candesartan 32 mg in nonresponders (systolic blood pressure (SBP) >140 and/or diastolic blood pressure (DBP) >90 mm Hg). We evaluated, at baseline and after 2, 4, 8, 12 and 16 weeks, clinic blood pressure, Ang II and PAI-1 antigen. Both imidapril and candesartan induced a similar SBP/DBP reduction (-19.4/16.8 and-19.5/16.3 mm Hg, respectively, P-1, P-1, P-1 at week 16, P-1, P
KW - candesartan
KW - fibrinolysis
KW - imidapril
KW - PAI-1
UR - http://www.scopus.com/inward/record.url?scp=82955188080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82955188080&partnerID=8YFLogxK
U2 - 10.1038/hr.2011.137
DO - 10.1038/hr.2011.137
M3 - Article
C2 - 21814211
AN - SCOPUS:82955188080
VL - 34
SP - 1321
EP - 1326
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 12
ER -