Role of anti-TGF-β antibodies in the treatment of renal injury

Elena Gagliardini, Ariela Benigni

Research output: Contribution to journalArticle

Abstract

Chronic kidney diseases are emerging world wide as a public health problem. Finding more effective renoprotective therapies is a major challenge in nephrology. Soon after the discovery of transforming growth factor-β (TGF-β), it became clear that this cytokine is widely expressed in almost all kidney cells. Overexpression of TGF-β isoforms and their receptors in the kidney of experimental animals is closely linked to renal fibrosis, a characteristic feature of progressive proteinuric nephropathies. Antibodies to TGF-β halt the development of diabetic and non-diabetic nephropathies. The effect is maximized by the addition of TGF-β antibodies on a background of angiotensin II blockade. Several studies have pointed to a role for TGF-β in instigating the fibrotic process characteristic of progressive human glomerulopathies, although the possible benefit of selective inhibition of TGF-β has not been described so far. This chapter discusses the role of TGF-β in renal fibrosis, and describes the renoprotective potential of strategies that interfere with TGF-β production in the kidney in experimental animals, as a new anti-fibrotic therapeutic approach.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalCytokine and Growth Factor Reviews
Volume17
Issue number1-2
DOIs
Publication statusPublished - Feb 2006

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Keywords

  • Angiotensin II blockers
  • Progressive nephropathies
  • Proteinuria
  • Renal fibrosis
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

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