Abstract
Apoptosis protease-activating factor-1 (Apaf-1) is a key regulator of the mitochondrial apoptotic pathway, being the central element of the multimeric apoptosome formed by procaspase 9, cytochrome c, and Apaf-1 itself. In this review, the principal aspects about Apaf-1 gene structure and function, and its role in the apoptotic machinery, are described. Moreover, the most recent findings about the involvement of this molecule in melanoma progression and chemoresistance, as well as the clinico-pathological relevance of these findings in the treatment of this deadly disease, are reported.
| Original language | English |
|---|---|
| Pages (from-to) | 811-818 |
| Number of pages | 8 |
| Journal | Experimental Dermatology |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2005 |
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Keywords
- Apaf-1
- Apoptosis
- Chemoresistance
- Melanoma progression
ASJC Scopus subject areas
- Dermatology
Cite this
Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance. / Campioni, Mara; Santini, Daniele; Tonini, Giuseppe; Murace, Raffaele; Dragonetti, Emanuele; Spugnini, Enrico P.; Baldi, Alfonso.
In: Experimental Dermatology, Vol. 14, No. 11, 11.2005, p. 811-818.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance
AU - Campioni, Mara
AU - Santini, Daniele
AU - Tonini, Giuseppe
AU - Murace, Raffaele
AU - Dragonetti, Emanuele
AU - Spugnini, Enrico P.
AU - Baldi, Alfonso
PY - 2005/11
Y1 - 2005/11
N2 - Apoptosis protease-activating factor-1 (Apaf-1) is a key regulator of the mitochondrial apoptotic pathway, being the central element of the multimeric apoptosome formed by procaspase 9, cytochrome c, and Apaf-1 itself. In this review, the principal aspects about Apaf-1 gene structure and function, and its role in the apoptotic machinery, are described. Moreover, the most recent findings about the involvement of this molecule in melanoma progression and chemoresistance, as well as the clinico-pathological relevance of these findings in the treatment of this deadly disease, are reported.
AB - Apoptosis protease-activating factor-1 (Apaf-1) is a key regulator of the mitochondrial apoptotic pathway, being the central element of the multimeric apoptosome formed by procaspase 9, cytochrome c, and Apaf-1 itself. In this review, the principal aspects about Apaf-1 gene structure and function, and its role in the apoptotic machinery, are described. Moreover, the most recent findings about the involvement of this molecule in melanoma progression and chemoresistance, as well as the clinico-pathological relevance of these findings in the treatment of this deadly disease, are reported.
KW - Apaf-1
KW - Apoptosis
KW - Chemoresistance
KW - Melanoma progression
UR - http://www.scopus.com/inward/record.url?scp=27744591569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744591569&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0625.2005.00360.x
DO - 10.1111/j.1600-0625.2005.00360.x
M3 - Article
C2 - 16232302
AN - SCOPUS:27744591569
VL - 14
SP - 811
EP - 818
JO - Experimental Dermatology
JF - Experimental Dermatology
SN - 0906-6705
IS - 11
ER -