Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance

Mara Campioni, Daniele Santini, Giuseppe Tonini, Raffaele Murace, Emanuele Dragonetti, Enrico P. Spugnini, Alfonso Baldi

Research output: Contribution to journalArticle

Abstract

Apoptosis protease-activating factor-1 (Apaf-1) is a key regulator of the mitochondrial apoptotic pathway, being the central element of the multimeric apoptosome formed by procaspase 9, cytochrome c, and Apaf-1 itself. In this review, the principal aspects about Apaf-1 gene structure and function, and its role in the apoptotic machinery, are described. Moreover, the most recent findings about the involvement of this molecule in melanoma progression and chemoresistance, as well as the clinico-pathological relevance of these findings in the treatment of this deadly disease, are reported.

Original languageEnglish
Pages (from-to)811-818
Number of pages8
JournalExperimental Dermatology
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Apaf-1
  • Apoptosis
  • Chemoresistance
  • Melanoma progression

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Campioni, M., Santini, D., Tonini, G., Murace, R., Dragonetti, E., Spugnini, E. P., & Baldi, A. (2005). Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance. Experimental Dermatology, 14(11), 811-818. https://doi.org/10.1111/j.1600-0625.2005.00360.x