Role of arginine metabolism in immunity and immunopathology

Elisa Peranzoni, Ilaria Marigo, Luigi Dolcetti, Stefano Ugel, Nada Sonda, Elisa Taschin, Barbara Mantelli, Vincenzo Bronte, Paola Zanovello

Research output: Contribution to journalArticle

Abstract

A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of the amino acid l-arginine. Myeloid cells exert various, often divergent, actions on the immune response through mechanisms that exploit mediators of this peculiar metabolic pathway, ranging from l-arginine itself to its downstream metabolites, like nitric oxide and polyamines. Various pathological situations, including neoplastic and autoimmune diseases, as well as injury repair and infections are discussed here, showing how l-arginine metabolism is able to play a dual role, both as an active protector and a possible threat to the organism.

Original languageEnglish
Pages (from-to)795-812
Number of pages18
JournalImmunobiology
Volume212
Issue number9-10
DOIs
Publication statusPublished - Jan 18 2008

    Fingerprint

Keywords

  • Arginine metabolism
  • Immune regulation
  • Immunopathology
  • Inflammation
  • Myeloid cells

ASJC Scopus subject areas

  • Immunology

Cite this

Peranzoni, E., Marigo, I., Dolcetti, L., Ugel, S., Sonda, N., Taschin, E., Mantelli, B., Bronte, V., & Zanovello, P. (2008). Role of arginine metabolism in immunity and immunopathology. Immunobiology, 212(9-10), 795-812. https://doi.org/10.1016/j.imbio.2007.09.008