Role of atrial natriuretic factor in renal adaptation to variation of salt intake in humans

Antonio Dal Canton, Giulio Romano, Giuseppe Conte, Luca De Nicola, Alfredo Caglioti, Patrizia Veniero, Francesco Uccello, Vittorio E. Andreucci

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This study was performed to define the extent to which atrial natriuretic factor (ANF) contributes to upregulate salt excretion in subjects eating a high-salt diet. Eight normal volunteers were first studied at low-salt diet (80 mmol NaCl/day); urinary sodium excretion (UNaV̇) and plasma ANF (PANF) were measured in the basal condition and during stepwise infusion of human α-ANF at 2, 4, 8, and 16 ng·min-1·kg-1. Then the same subjects were shifted to a high-salt diet (400 mmol/day), and UNaV̇ and PANF were measured in the new balance condition. At low-salt diet, UNaV̇ averaged 0.069 meq/min, and PANF averaged 21 pg/ ml; infusion of human α-ANF raised stepwise both UNaV̇ and PANF (means in meq/min and pg/ml, respectively, were 0.177 and 46, 0.218 and 76, 0.360 and 86, and 0.601 and 182). Infusion of ANF caused a progressive fall of plasma aldosterone and plasma renin activity. Mean UNaV̇ and PANF at high-salt diet were 0.301 meq/min and 35 pg/ml. Thus, by increasing experimentally PANF in a low-salt diet condition to the levels occurring physiologically in a high-salt diet condition, a significant rise in UNaV̇ is evoked, which accounts for ∼50% of the rise of UNaV̇ that is necessary to balance the increased salt intake.

Original languageEnglish
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Issue number6 27-6
Publication statusPublished - 1990


  • Dietary salt intake
  • Sodium excretion

ASJC Scopus subject areas

  • Physiology


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