Role of BAG3 protein in leukemia cell survival and response to therapy

Alessandra Rosati, Anna Basile, Antonia Falco, Morena d'Avenia, Michelina Festa, Vincenzo Graziano, Vincenzo De Laurenzi, Claudio Arra, Maria Pascale, Maria Caterina Turco

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of BAG3, a member of the BAG family of heat shock protein (Hsp) 70 - cochaperones, to sustain the survival of human primary B-CLL and ALL cells was recognized about nine years ago. Since then, the anti-apoptotic activity of BAG3 has been confirmed in other tumor types, where it has been shown to regulate the intracellular concentration and localization of apoptosis-regulating factors, including NF-κB-activating (IKKγ) and Bcl2-family (Bax) proteins. Furthermore, growing evidences support its role in lymphoid and myeloid leukemia response to therapy. Moreover in the last years, the contribution of BAG3 to autophagy, a process known to be involved in the pathogenesis and response to therapy of leukemia cells, has been disclosed, opening a new avenue for the interpretation of the role of this protein in leukemias' biology.

Original languageEnglish
Pages (from-to)365-369
Number of pages5
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1826
Issue number2
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Apoptosis
  • Autophagy
  • BAG3
  • Cancer
  • Leukemia

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

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