TY - JOUR
T1 - Role of BAG3 protein in leukemia cell survival and response to therapy
AU - Rosati, Alessandra
AU - Basile, Anna
AU - Falco, Antonia
AU - d'Avenia, Morena
AU - Festa, Michelina
AU - Graziano, Vincenzo
AU - De Laurenzi, Vincenzo
AU - Arra, Claudio
AU - Pascale, Maria
AU - Turco, Maria Caterina
PY - 2012/12
Y1 - 2012/12
N2 - The ability of BAG3, a member of the BAG family of heat shock protein (Hsp) 70 - cochaperones, to sustain the survival of human primary B-CLL and ALL cells was recognized about nine years ago. Since then, the anti-apoptotic activity of BAG3 has been confirmed in other tumor types, where it has been shown to regulate the intracellular concentration and localization of apoptosis-regulating factors, including NF-κB-activating (IKKγ) and Bcl2-family (Bax) proteins. Furthermore, growing evidences support its role in lymphoid and myeloid leukemia response to therapy. Moreover in the last years, the contribution of BAG3 to autophagy, a process known to be involved in the pathogenesis and response to therapy of leukemia cells, has been disclosed, opening a new avenue for the interpretation of the role of this protein in leukemias' biology.
AB - The ability of BAG3, a member of the BAG family of heat shock protein (Hsp) 70 - cochaperones, to sustain the survival of human primary B-CLL and ALL cells was recognized about nine years ago. Since then, the anti-apoptotic activity of BAG3 has been confirmed in other tumor types, where it has been shown to regulate the intracellular concentration and localization of apoptosis-regulating factors, including NF-κB-activating (IKKγ) and Bcl2-family (Bax) proteins. Furthermore, growing evidences support its role in lymphoid and myeloid leukemia response to therapy. Moreover in the last years, the contribution of BAG3 to autophagy, a process known to be involved in the pathogenesis and response to therapy of leukemia cells, has been disclosed, opening a new avenue for the interpretation of the role of this protein in leukemias' biology.
KW - Apoptosis
KW - Autophagy
KW - BAG3
KW - Cancer
KW - Leukemia
UR - http://www.scopus.com/inward/record.url?scp=84863093411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863093411&partnerID=8YFLogxK
U2 - 10.1016/j.bbcan.2012.06.001
DO - 10.1016/j.bbcan.2012.06.001
M3 - Article
C2 - 22710027
AN - SCOPUS:84863093411
VL - 1826
SP - 365
EP - 369
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
SN - 0304-419X
IS - 2
ER -