Role of bcii polymorphism of β-chain fibrinogen gene in the risk of familial myocardial infarction (AMI)

F. Zito, L. Iacoviello, A. Pi Caslelnuovo, D. De Lucia, A. D'Orazio, C. Amore, M. B. Donali

Research output: Contribution to journalArticlepeer-review

Abstract

High plasma fibrinogen levels are considered a major risk factor for arterial thrombotic diseases. Whether fibrinogen genotype is associated with different levels of fibrinogen or with arterial thrombosis has not been well established so far. We focussed our study on the Bell polymorphism in the -chain of the fibrinogen gene: the polymerase chain reaction was followed by the use of the Bell restriction enzyme to detect alleles B1 and B2. Genotype analyses were performed on one hundred AMI patients who had a familial tendency to arterial thrombosis (with at least one first degree relative suffering of AMI or stroke before 65 years) and one hundred eighty controls (matched for sex, age and regional area), aged 42-74, recruited all over Italy. There was a high difference in allele frequency between cases and controls: the B1 and B2 allele frequencies were respectively 0.82 and 0.18 in controls, and 0.71 and 0.29 in AMI patients (*p

Original languageEnglish
Pages (from-to)76
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 3
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Hematology

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