Role of brain biopsy in the management of focal brain lesions in HIV- infected patients

A. Antinori, Adriana Ammassari, R. Luzzati, A. Castagna, R. Maserati, G. Rizzardini, A. Ridolfo, M. Fasan, E. Vaccher, G. Landonio, M. Scerrati, A. Rocca, G. Butti, A. Nicolato, A. Lazzarin, U. Tirelli

Research output: Contribution to journalArticle

Abstract

In this multicenter, retrospective study of 160 brain biopsies in the assessment of HIV-related focal brain lesions, diagnostic sensitivity was acceptable (87%), but the procedure carried considerable morbidity (7.5%) and mortality (3.1%). Moreover, it is not always possible to initiate the changes in therapy indicated by the results, and overall survival remains poor, with a median of 2 months. Criteria for brain biopsy for the diagnosis of focal brain lesions should be redefined to include selected patients for whom a less invasive approach does not yield a definitive diagnosis.

Original languageEnglish
Pages (from-to)993-997
Number of pages5
JournalNeurology
Volume54
Issue number4
Publication statusPublished - Feb 22 2000

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Keywords

  • Brain biopsy
  • Focal brain lesion
  • HIV

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Antinori, A., Ammassari, A., Luzzati, R., Castagna, A., Maserati, R., Rizzardini, G., Ridolfo, A., Fasan, M., Vaccher, E., Landonio, G., Scerrati, M., Rocca, A., Butti, G., Nicolato, A., Lazzarin, A., & Tirelli, U. (2000). Role of brain biopsy in the management of focal brain lesions in HIV- infected patients. Neurology, 54(4), 993-997.