Role of breast surgery in T1-3 breast cancer patients with synchronous bone metastases

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5 Citations (Scopus)

Abstract

The impact of breast surgery on survival of metastatic breast cancer (MBC) patients is controversial. We addressed the question in a mono-institutional series of MBC patients with synchronous bone metastases. We identified 187 consecutive women diagnosed between 2000 and 2008 with locally operable (T1-T3) MBC, synchronous bone metastases, with no other distant sites being involved. Progression-free survival (PFS) and overall survival (OS) were compared between operated and non-operated patients. Median age was 51 years; 92 % of the women had a hormone-positive tumor. At the time of diagnosis, 131 patients out of 187 (70 %) underwent surgery. Operated and non-operated patients differed in terms of number of bone metastatic sites: a single metastasis was detected in 35 (28 %) operated, and 6 (11 %) non-operated cases (P = 0.01). No other significant differences were observed. The multi-adjusted hazard ratio was 0.63 (95 % CI 0.43-0.92) for PFS and 0.64 (95 % CI 0.41-0.99) for OS in favor of surgery. The 5-year cumulative incidence of ipsilateral breast skin progressions among non-operated patients was 18 %. In this large and homogeneous series of MBC patients with synchronous bone metastases, the role of breast surgery had a favorable impact on both disease progression and mortality.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalBreast Cancer Research and Treatment
Volume138
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Breast
Neoplasm Metastasis
Bone and Bones
Breast Neoplasms
Disease-Free Survival
Survival
Bone Neoplasms
Breast Cancer 3
Disease Progression
Hormones
Skin
Mortality
Incidence
Neoplasms

Keywords

  • Advanced breast cancer
  • Surgery
  • Survival
  • Synchronous metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "Role of breast surgery in T1-3 breast cancer patients with synchronous bone metastases",
abstract = "The impact of breast surgery on survival of metastatic breast cancer (MBC) patients is controversial. We addressed the question in a mono-institutional series of MBC patients with synchronous bone metastases. We identified 187 consecutive women diagnosed between 2000 and 2008 with locally operable (T1-T3) MBC, synchronous bone metastases, with no other distant sites being involved. Progression-free survival (PFS) and overall survival (OS) were compared between operated and non-operated patients. Median age was 51 years; 92 {\%} of the women had a hormone-positive tumor. At the time of diagnosis, 131 patients out of 187 (70 {\%}) underwent surgery. Operated and non-operated patients differed in terms of number of bone metastatic sites: a single metastasis was detected in 35 (28 {\%}) operated, and 6 (11 {\%}) non-operated cases (P = 0.01). No other significant differences were observed. The multi-adjusted hazard ratio was 0.63 (95 {\%} CI 0.43-0.92) for PFS and 0.64 (95 {\%} CI 0.41-0.99) for OS in favor of surgery. The 5-year cumulative incidence of ipsilateral breast skin progressions among non-operated patients was 18 {\%}. In this large and homogeneous series of MBC patients with synchronous bone metastases, the role of breast surgery had a favorable impact on both disease progression and mortality.",
keywords = "Advanced breast cancer, Surgery, Survival, Synchronous metastasis",
author = "Edoardo Botteri and Elisabetta Munzone and Mattia Intra and Vincenzo Bagnardi and Nicole Rotmensz and Barbara Bazolli and Bruno Montanari and Gaetano Aurilio and Angela Sciandivasci and Angela Esposito and Gianmatteo Pagani and Laura Adamoli and Giuseppe Viale and Franco Nol{\`e} and Aron Goldhirsch",
year = "2013",
doi = "10.1007/s10549-013-2449-6",
language = "English",
volume = "138",
pages = "303--310",
journal = "Breast Cancer Research and Treatment",
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T1 - Role of breast surgery in T1-3 breast cancer patients with synchronous bone metastases

AU - Botteri, Edoardo

AU - Munzone, Elisabetta

AU - Intra, Mattia

AU - Bagnardi, Vincenzo

AU - Rotmensz, Nicole

AU - Bazolli, Barbara

AU - Montanari, Bruno

AU - Aurilio, Gaetano

AU - Sciandivasci, Angela

AU - Esposito, Angela

AU - Pagani, Gianmatteo

AU - Adamoli, Laura

AU - Viale, Giuseppe

AU - Nolè, Franco

AU - Goldhirsch, Aron

PY - 2013

Y1 - 2013

N2 - The impact of breast surgery on survival of metastatic breast cancer (MBC) patients is controversial. We addressed the question in a mono-institutional series of MBC patients with synchronous bone metastases. We identified 187 consecutive women diagnosed between 2000 and 2008 with locally operable (T1-T3) MBC, synchronous bone metastases, with no other distant sites being involved. Progression-free survival (PFS) and overall survival (OS) were compared between operated and non-operated patients. Median age was 51 years; 92 % of the women had a hormone-positive tumor. At the time of diagnosis, 131 patients out of 187 (70 %) underwent surgery. Operated and non-operated patients differed in terms of number of bone metastatic sites: a single metastasis was detected in 35 (28 %) operated, and 6 (11 %) non-operated cases (P = 0.01). No other significant differences were observed. The multi-adjusted hazard ratio was 0.63 (95 % CI 0.43-0.92) for PFS and 0.64 (95 % CI 0.41-0.99) for OS in favor of surgery. The 5-year cumulative incidence of ipsilateral breast skin progressions among non-operated patients was 18 %. In this large and homogeneous series of MBC patients with synchronous bone metastases, the role of breast surgery had a favorable impact on both disease progression and mortality.

AB - The impact of breast surgery on survival of metastatic breast cancer (MBC) patients is controversial. We addressed the question in a mono-institutional series of MBC patients with synchronous bone metastases. We identified 187 consecutive women diagnosed between 2000 and 2008 with locally operable (T1-T3) MBC, synchronous bone metastases, with no other distant sites being involved. Progression-free survival (PFS) and overall survival (OS) were compared between operated and non-operated patients. Median age was 51 years; 92 % of the women had a hormone-positive tumor. At the time of diagnosis, 131 patients out of 187 (70 %) underwent surgery. Operated and non-operated patients differed in terms of number of bone metastatic sites: a single metastasis was detected in 35 (28 %) operated, and 6 (11 %) non-operated cases (P = 0.01). No other significant differences were observed. The multi-adjusted hazard ratio was 0.63 (95 % CI 0.43-0.92) for PFS and 0.64 (95 % CI 0.41-0.99) for OS in favor of surgery. The 5-year cumulative incidence of ipsilateral breast skin progressions among non-operated patients was 18 %. In this large and homogeneous series of MBC patients with synchronous bone metastases, the role of breast surgery had a favorable impact on both disease progression and mortality.

KW - Advanced breast cancer

KW - Surgery

KW - Survival

KW - Synchronous metastasis

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U2 - 10.1007/s10549-013-2449-6

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