Abstract
Background:Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF.Methodologies:456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method.Principal Findings:The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 μmol/L; p
| Original language | English |
|---|---|
| Article number | e495 |
| Journal | PLoS One |
| Volume | 2 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2007 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility. / Giusti, Betti; Gori, Anna Maria; Marcucci, Rossella; Sestini, Ilaria; Saracini, Claudia; Sticchi, Elena; Gensini, Francesca; Fatini, Cinzia; Abbate, Rosanna; Gensini, Gian Franco.
In: PLoS One, Vol. 2, No. 6, e495, 2007.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility
AU - Giusti, Betti
AU - Gori, Anna Maria
AU - Marcucci, Rossella
AU - Sestini, Ilaria
AU - Saracini, Claudia
AU - Sticchi, Elena
AU - Gensini, Francesca
AU - Fatini, Cinzia
AU - Abbate, Rosanna
AU - Gensini, Gian Franco
PY - 2007
Y1 - 2007
N2 - Background:Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF.Methodologies:456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method.Principal Findings:The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 μmol/L; p
AB - Background:Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF.Methodologies:456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method.Principal Findings:The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 μmol/L; p
UR - http://www.scopus.com/inward/record.url?scp=77951649037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951649037&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0000495
DO - 10.1371/journal.pone.0000495
M3 - Article
C2 - 17551576
AN - SCOPUS:77951649037
VL - 2
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 6
M1 - e495
ER -