Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility

Betti Giusti; Anna Maria Gori; Rossella Marcucci; Ilaria Sestini; Claudia Saracini; Elena Sticchi; Francesca Gensini; Cinzia Fatini; Rosanna Abbate; Gian Franco Gensini

doi:10.1371/journal.pone.0000495

Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility

Betti Giusti, Anna Maria Gori, Rossella Marcucci, Ilaria Sestini, Claudia Saracini, Elena Sticchi, Francesca Gensini, Cinzia Fatini, Rosanna Abbate, Gian Franco Gensini

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Background:Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF.Methodologies:456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method.Principal Findings:The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 μmol/L; p

Original language	English
Article number	e495
Journal	PLoS One
Volume	2
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0000495
Publication status	Published - 2007

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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title = "Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility",

abstract = "Background:Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF.Methodologies:456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method.Principal Findings:The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 μmol/L; p",

author = "Betti Giusti and Gori, {Anna Maria} and Rossella Marcucci and Ilaria Sestini and Claudia Saracini and Elena Sticchi and Francesca Gensini and Cinzia Fatini and Rosanna Abbate and Gensini, {Gian Franco}",

year = "2007",

doi = "10.1371/journal.pone.0000495",

language = "English",

volume = "2",

journal = "PLoS One",

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T1 - Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility

AU - Giusti, Betti

AU - Gori, Anna Maria

AU - Marcucci, Rossella

AU - Sestini, Ilaria

AU - Saracini, Claudia

AU - Sticchi, Elena

AU - Gensini, Francesca

AU - Fatini, Cinzia

AU - Abbate, Rosanna

AU - Gensini, Gian Franco

PY - 2007

Y1 - 2007

N2 - Background:Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF.Methodologies:456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method.Principal Findings:The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 μmol/L; p

AB - Background:Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF.Methodologies:456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method.Principal Findings:The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 μmol/L; p

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Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility

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