Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility

Betti Giusti, Anna Maria Gori, Rossella Marcucci, Ilaria Sestini, Claudia Saracini, Elena Sticchi, Francesca Gensini, Cinzia Fatini, Rosanna Abbate, Gian Franco Gensini

Research output: Contribution to journalArticle

Abstract

Background:Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF.Methodologies:456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756G MTR, and -786C/T eNOS gene polymorphisms. Hcy was determined by an immunoassay method.Principal Findings:The genotype distribution of the four polymorphisms as well as genotype combinations did not differ in patients and controls. Hcy was higher in patients than in controls (15.2, 95%CI 14.7-15.7 vs 11.3, 95%CI 11.0-11.6 μmol/L; p

Original languageEnglish
Article numbere495
JournalPLoS One
Volume2
Issue number6
DOIs
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Giusti, B., Gori, A. M., Marcucci, R., Sestini, I., Saracini, C., Sticchi, E., Gensini, F., Fatini, C., Abbate, R., & Gensini, G. F. (2007). Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility. PLoS One, 2(6), [e495]. https://doi.org/10.1371/journal.pone.0000495