Role of calcitonin gene-related peptide and kinins in post-ischemic intestinal reperfusion

Paolo Madeddu, Costanza Emanueli, Maria Bonaria Salis, Anna Franca Milia, Tiziana Stacca, Luisa Carta, Alessandra Pinna, Maria Deiana, Leonardo Gaspa

Research output: Contribution to journalArticle

Abstract

The involvement of kinins, calcitonin gene-related peptide (CGRP), and tachykinins during mesenteric post-ischemic reperfusion was studied in anesthetized rats by using antagonists for bradykinin (BK) B1, BK B2, CGRP1, or tachykinin NK1 receptor, or by capsaicin-induced desensitization. B1, B2, or CGRP1 receptor antagonists or desensitization attenuated the transient hypotension and plasma protein and leukocyte infiltration of intestinal wall observed during post-ischemic reperfusion. These effects were abolished by the combination of B2 and CGRP1 blockade as well as by B2 antagonism in capsaicinized rats, while NK1 blockade was ineffective. Our results suggest that kinins and CGRP contribute to systemic vasodilatation and microvascular leakage during mesenteric reperfusion. Pharmacological blockade of these systems could help preventing hypotension and intestinal injury consequent to reperfusion.

Original languageEnglish
Pages (from-to)915-922
Number of pages8
JournalPeptides
Volume22
Issue number6
DOIs
Publication statusPublished - 2001

Keywords

  • Calcitonin gene-related peptide
  • Hypotension
  • Intestinal reperfusion
  • Kinins
  • Plasma extravasation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Madeddu, P., Emanueli, C., Bonaria Salis, M., Franca Milia, A., Stacca, T., Carta, L., Pinna, A., Deiana, M., & Gaspa, L. (2001). Role of calcitonin gene-related peptide and kinins in post-ischemic intestinal reperfusion. Peptides, 22(6), 915-922. https://doi.org/10.1016/S0196-9781(01)00417-X