Abstract
Background and Aim: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD. Methods: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non-responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed. Results: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications. Conclusion: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 461-466 |
| Journal | Digestive Endoscopy |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2018 |
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Keywords
- Capsule endoscopy
- Celiac disease
- Gluten
- Lymphoma
- Non-responsive celiac disease
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Gastroenterology
Cite this
Role of capsule endoscopy in alarm features and non-responsive celiac disease : A European multicenter study. / Perez-Cuadrado-Robles, Enrique; Lujan-Sanchis, Marisol; Elli, Luca; Juanmartinena-Fernandez, Jose Francisco; Garcia-Lledo, Javier; Ruano-Diaz, Lucia; Egea-Valenzuela, Juan; Jimenez-Garcia, Victoria Alejandra; Arguelles-Arias, Federico; Juan-Acosta, Mileidis San; Carretero-Ribon, Cristina; Alonso-Lazaro, Noelia; Rosa, Bruno; Sanchez-Ceballos, Francisco; Lopez-Higueras, Antonio; Fernandez-Urien-Sainz, Ignacio; Branchi, Federica; Valle-Muñoz, Julio; Borque-Barrera, Pilar; Gonzalez-Vazquez, Santiago; Pons-Beltran, Vicente; Xavier, Sofia; Gonzalez-Suarez, Begona; Herrerias-Gutierrez, Juan Manuel; Perez-Cuadrado-Martinez, Enrique; Sempere-Garcia-Arguelles, Javier.
In: Digestive Endoscopy, Vol. 30, No. 4, 2018, p. 461-466.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of capsule endoscopy in alarm features and non-responsive celiac disease
T2 - A European multicenter study
AU - Perez-Cuadrado-Robles, Enrique
AU - Lujan-Sanchis, Marisol
AU - Elli, Luca
AU - Juanmartinena-Fernandez, Jose Francisco
AU - Garcia-Lledo, Javier
AU - Ruano-Diaz, Lucia
AU - Egea-Valenzuela, Juan
AU - Jimenez-Garcia, Victoria Alejandra
AU - Arguelles-Arias, Federico
AU - Juan-Acosta, Mileidis San
AU - Carretero-Ribon, Cristina
AU - Alonso-Lazaro, Noelia
AU - Rosa, Bruno
AU - Sanchez-Ceballos, Francisco
AU - Lopez-Higueras, Antonio
AU - Fernandez-Urien-Sainz, Ignacio
AU - Branchi, Federica
AU - Valle-Muñoz, Julio
AU - Borque-Barrera, Pilar
AU - Gonzalez-Vazquez, Santiago
AU - Pons-Beltran, Vicente
AU - Xavier, Sofia
AU - Gonzalez-Suarez, Begona
AU - Herrerias-Gutierrez, Juan Manuel
AU - Perez-Cuadrado-Martinez, Enrique
AU - Sempere-Garcia-Arguelles, Javier
PY - 2018
Y1 - 2018
N2 - Background and Aim: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD. Methods: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non-responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed. Results: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications. Conclusion: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients.
AB - Background and Aim: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD. Methods: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non-responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed. Results: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications. Conclusion: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients.
KW - Capsule endoscopy
KW - Celiac disease
KW - Gluten
KW - Lymphoma
KW - Non-responsive celiac disease
UR - http://www.scopus.com/inward/record.url?scp=85040789794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040789794&partnerID=8YFLogxK
U2 - 10.1111/den.13002
DO - 10.1111/den.13002
M3 - Article
AN - SCOPUS:85040789794
VL - 30
SP - 461
EP - 466
JO - Digestive Endoscopy
JF - Digestive Endoscopy
SN - 0915-5635
IS - 4
ER -