Role of capsule endoscopy in alarm features and non-responsive celiac disease: A European multicenter study

Enrique Perez-Cuadrado-Robles, Marisol Lujan-Sanchis, Luca Elli, Jose Francisco Juanmartinena-Fernandez, Javier Garcia-Lledo, Lucia Ruano-Diaz, Juan Egea-Valenzuela, Victoria Alejandra Jimenez-Garcia, Federico Arguelles-Arias, Mileidis San Juan-Acosta, Cristina Carretero-Ribon, Noelia Alonso-Lazaro, Bruno Rosa, Francisco Sanchez-Ceballos, Antonio Lopez-Higueras, Ignacio Fernandez-Urien-Sainz, Federica Branchi, Julio Valle-Muñoz, Pilar Borque-Barrera, Santiago Gonzalez-VazquezVicente Pons-Beltran, Sofia Xavier, Begona Gonzalez-Suarez, Juan Manuel Herrerias-Gutierrez, Enrique Perez-Cuadrado-Martinez, Javier Sempere-Garcia-Arguelles

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and Aim: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD. Methods: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non-responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed. Results: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications. Conclusion: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients.

Original languageEnglish
Pages (from-to)461-466
JournalDigestive Endoscopy
Volume30
Issue number4
DOIs
Publication statusPublished - 2018

Fingerprint

Capsule Endoscopy
Celiac Disease
Multicenter Studies
Neuroendocrine Tumors
Crohn Disease
Abdomen
Lymphoma
Mucous Membrane
Retrospective Studies
Safety

Keywords

  • Capsule endoscopy
  • Celiac disease
  • Gluten
  • Lymphoma
  • Non-responsive celiac disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Perez-Cuadrado-Robles, E., Lujan-Sanchis, M., Elli, L., Juanmartinena-Fernandez, J. F., Garcia-Lledo, J., Ruano-Diaz, L., ... Sempere-Garcia-Arguelles, J. (2018). Role of capsule endoscopy in alarm features and non-responsive celiac disease: A European multicenter study. Digestive Endoscopy, 30(4), 461-466. https://doi.org/10.1111/den.13002

Role of capsule endoscopy in alarm features and non-responsive celiac disease : A European multicenter study. / Perez-Cuadrado-Robles, Enrique; Lujan-Sanchis, Marisol; Elli, Luca; Juanmartinena-Fernandez, Jose Francisco; Garcia-Lledo, Javier; Ruano-Diaz, Lucia; Egea-Valenzuela, Juan; Jimenez-Garcia, Victoria Alejandra; Arguelles-Arias, Federico; Juan-Acosta, Mileidis San; Carretero-Ribon, Cristina; Alonso-Lazaro, Noelia; Rosa, Bruno; Sanchez-Ceballos, Francisco; Lopez-Higueras, Antonio; Fernandez-Urien-Sainz, Ignacio; Branchi, Federica; Valle-Muñoz, Julio; Borque-Barrera, Pilar; Gonzalez-Vazquez, Santiago; Pons-Beltran, Vicente; Xavier, Sofia; Gonzalez-Suarez, Begona; Herrerias-Gutierrez, Juan Manuel; Perez-Cuadrado-Martinez, Enrique; Sempere-Garcia-Arguelles, Javier.

In: Digestive Endoscopy, Vol. 30, No. 4, 2018, p. 461-466.

Research output: Contribution to journalArticle

Perez-Cuadrado-Robles, E, Lujan-Sanchis, M, Elli, L, Juanmartinena-Fernandez, JF, Garcia-Lledo, J, Ruano-Diaz, L, Egea-Valenzuela, J, Jimenez-Garcia, VA, Arguelles-Arias, F, Juan-Acosta, MS, Carretero-Ribon, C, Alonso-Lazaro, N, Rosa, B, Sanchez-Ceballos, F, Lopez-Higueras, A, Fernandez-Urien-Sainz, I, Branchi, F, Valle-Muñoz, J, Borque-Barrera, P, Gonzalez-Vazquez, S, Pons-Beltran, V, Xavier, S, Gonzalez-Suarez, B, Herrerias-Gutierrez, JM, Perez-Cuadrado-Martinez, E & Sempere-Garcia-Arguelles, J 2018, 'Role of capsule endoscopy in alarm features and non-responsive celiac disease: A European multicenter study', Digestive Endoscopy, vol. 30, no. 4, pp. 461-466. https://doi.org/10.1111/den.13002
Perez-Cuadrado-Robles E, Lujan-Sanchis M, Elli L, Juanmartinena-Fernandez JF, Garcia-Lledo J, Ruano-Diaz L et al. Role of capsule endoscopy in alarm features and non-responsive celiac disease: A European multicenter study. Digestive Endoscopy. 2018;30(4):461-466. https://doi.org/10.1111/den.13002
Perez-Cuadrado-Robles, Enrique ; Lujan-Sanchis, Marisol ; Elli, Luca ; Juanmartinena-Fernandez, Jose Francisco ; Garcia-Lledo, Javier ; Ruano-Diaz, Lucia ; Egea-Valenzuela, Juan ; Jimenez-Garcia, Victoria Alejandra ; Arguelles-Arias, Federico ; Juan-Acosta, Mileidis San ; Carretero-Ribon, Cristina ; Alonso-Lazaro, Noelia ; Rosa, Bruno ; Sanchez-Ceballos, Francisco ; Lopez-Higueras, Antonio ; Fernandez-Urien-Sainz, Ignacio ; Branchi, Federica ; Valle-Muñoz, Julio ; Borque-Barrera, Pilar ; Gonzalez-Vazquez, Santiago ; Pons-Beltran, Vicente ; Xavier, Sofia ; Gonzalez-Suarez, Begona ; Herrerias-Gutierrez, Juan Manuel ; Perez-Cuadrado-Martinez, Enrique ; Sempere-Garcia-Arguelles, Javier. / Role of capsule endoscopy in alarm features and non-responsive celiac disease : A European multicenter study. In: Digestive Endoscopy. 2018 ; Vol. 30, No. 4. pp. 461-466.
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abstract = "Background and Aim: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD. Methods: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2{\%} males) who underwent CE for alarm symptoms (n = 86, 45.5{\%}) or non-responsive CD (n = 103, 54.5{\%}) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed. Results: Capsule endoscopy was completed in 95.2{\%} of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2{\%}, detecting atrophic mucosa (n = 92, 48.7{\%}), ulcerative jejunoileitis (n = 21, 11.1{\%}), intestinal lymphoma (n = 7, 3.7{\%}) and other enteropathies (n = 7, 3.7{\%}, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8{\%} vs 59.3{\%}, P = 0.035). The new findings of the CE modified management in 59.3{\%} of the cases. There were no major complications. Conclusion: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients.",
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author = "Enrique Perez-Cuadrado-Robles and Marisol Lujan-Sanchis and Luca Elli and Juanmartinena-Fernandez, {Jose Francisco} and Javier Garcia-Lledo and Lucia Ruano-Diaz and Juan Egea-Valenzuela and Jimenez-Garcia, {Victoria Alejandra} and Federico Arguelles-Arias and Juan-Acosta, {Mileidis San} and Cristina Carretero-Ribon and Noelia Alonso-Lazaro and Bruno Rosa and Francisco Sanchez-Ceballos and Antonio Lopez-Higueras and Ignacio Fernandez-Urien-Sainz and Federica Branchi and Julio Valle-Mu{\~n}oz and Pilar Borque-Barrera and Santiago Gonzalez-Vazquez and Vicente Pons-Beltran and Sofia Xavier and Begona Gonzalez-Suarez and Herrerias-Gutierrez, {Juan Manuel} and Enrique Perez-Cuadrado-Martinez and Javier Sempere-Garcia-Arguelles",
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T1 - Role of capsule endoscopy in alarm features and non-responsive celiac disease

T2 - A European multicenter study

AU - Perez-Cuadrado-Robles, Enrique

AU - Lujan-Sanchis, Marisol

AU - Elli, Luca

AU - Juanmartinena-Fernandez, Jose Francisco

AU - Garcia-Lledo, Javier

AU - Ruano-Diaz, Lucia

AU - Egea-Valenzuela, Juan

AU - Jimenez-Garcia, Victoria Alejandra

AU - Arguelles-Arias, Federico

AU - Juan-Acosta, Mileidis San

AU - Carretero-Ribon, Cristina

AU - Alonso-Lazaro, Noelia

AU - Rosa, Bruno

AU - Sanchez-Ceballos, Francisco

AU - Lopez-Higueras, Antonio

AU - Fernandez-Urien-Sainz, Ignacio

AU - Branchi, Federica

AU - Valle-Muñoz, Julio

AU - Borque-Barrera, Pilar

AU - Gonzalez-Vazquez, Santiago

AU - Pons-Beltran, Vicente

AU - Xavier, Sofia

AU - Gonzalez-Suarez, Begona

AU - Herrerias-Gutierrez, Juan Manuel

AU - Perez-Cuadrado-Martinez, Enrique

AU - Sempere-Garcia-Arguelles, Javier

PY - 2018

Y1 - 2018

N2 - Background and Aim: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD. Methods: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non-responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed. Results: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications. Conclusion: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients.

AB - Background and Aim: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD. Methods: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non-responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed. Results: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications. Conclusion: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients.

KW - Capsule endoscopy

KW - Celiac disease

KW - Gluten

KW - Lymphoma

KW - Non-responsive celiac disease

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