TY - JOUR
T1 - Role of cardiac dyssynchrony and resynchronization therapy in functional mitral regurgitation
AU - Spartera, Marco
AU - Galderisi, Maurizio
AU - Mele, Donato
AU - Cameli, Matteo
AU - D'Andrea, Antonello
AU - Rossi, Andrea
AU - Mondillo, Sergio
AU - Novo, Giuseppina
AU - Esposito, Roberta
AU - D'Ascenzi, Flavio
AU - Montisci, Roberta
AU - Gallina, Sabina
AU - Margonato, Alberto
AU - Agricola, Eustachio
PY - 2016
Y1 - 2016
N2 - Functional mitral regurgitation (FMR) is a common complication of left ventricle (LV) dysfunction and remodelling. Recently, it has been recognized as an independent prognostic factor in both ischaemic and non-ischaemic LV dysfunctions. In this review article, we discuss the mechanisms through which cardiac dyssynchrony is involved in FMR pathophysiologic cascade and how cardiac resynchronization therapy (CRT) can have therapeutic effects on FMR by reverting specific dyssynchrony pathways.We analyse recent clinical trials focusing on CRT impact on FMR in 'real-world' patients, the limits and future perspectives that could eventually generate new predictors of CRT response in terms of FMR reduction. Finally, we propose a practical diagnostic and therapeutic strategy for the management of symptomatic patients with severe LV dysfunction and concomitant 'prognostic' FMR.
AB - Functional mitral regurgitation (FMR) is a common complication of left ventricle (LV) dysfunction and remodelling. Recently, it has been recognized as an independent prognostic factor in both ischaemic and non-ischaemic LV dysfunctions. In this review article, we discuss the mechanisms through which cardiac dyssynchrony is involved in FMR pathophysiologic cascade and how cardiac resynchronization therapy (CRT) can have therapeutic effects on FMR by reverting specific dyssynchrony pathways.We analyse recent clinical trials focusing on CRT impact on FMR in 'real-world' patients, the limits and future perspectives that could eventually generate new predictors of CRT response in terms of FMR reduction. Finally, we propose a practical diagnostic and therapeutic strategy for the management of symptomatic patients with severe LV dysfunction and concomitant 'prognostic' FMR.
KW - Cardiac resynchronization
KW - Mitral regurgitation
KW - Ventricular dyssynchrony
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U2 - 10.1093/ehjci/jev352
DO - 10.1093/ehjci/jev352
M3 - Review article
AN - SCOPUS:84979030799
VL - 17
SP - 471
EP - 480
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
SN - 2047-2404
IS - 5
ER -