Role of CD4 cytotoxic T lymphocytes in the control of viral diseases and cancer

Debora Martorelli; Elena Muraro; Anna Merlo; Riccardo Turrini; Antonio Rosato; Riccardo Dolcetti

doi:10.3109/08830185.2010.489658

Role of CD4 cytotoxic T lymphocytes in the control of viral diseases and cancer

Debora Martorelli, Elena Muraro, Anna Merlo, Riccardo Turrini, Antonio Rosato, Riccardo Dolcetti

Research output: Contribution to journal › Article › peer-review

Abstract

Our knowledge on the physiological role of CD⁴ T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD⁴ T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pathogenic infections and in mediating antitumor immune responses. On these bases, several immunotherapeutic approaches exploiting the cytotoxic properties of CD⁴ T cells are under investigation. This review summarizes available data supporting the functional and therapeutic relevance of cytotoxic CD⁴ T cells, with a particular focus on Epstein-Barr virus (EBV)-related disorders. ©

Original language	English
Pages (from-to)	371-402
Number of pages	32
Journal	International Reviews of Immunology
Volume	29
Issue number	4
DOIs	https://doi.org/10.3109/08830185.2010.489658
Publication status	Published - Jul 2010

Keywords

Cancer
CD T cells
Cytotoxicity
Epstein-Barr virus

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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AU - Muraro, Elena

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AU - Turrini, Riccardo

AU - Rosato, Antonio

AU - Dolcetti, Riccardo

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AB - Our knowledge on the physiological role of CD4 T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD4 T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pathogenic infections and in mediating antitumor immune responses. On these bases, several immunotherapeutic approaches exploiting the cytotoxic properties of CD4 T cells are under investigation. This review summarizes available data supporting the functional and therapeutic relevance of cytotoxic CD4 T cells, with a particular focus on Epstein-Barr virus (EBV)-related disorders. ©

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KW - Cytotoxicity

KW - Epstein-Barr virus

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Role of CD4 cytotoxic T lymphocytes in the control of viral diseases and cancer

Abstract

Keywords

ASJC Scopus subject areas

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