Role of CD40 and B7 costimulators in inflammatory bowel diseases

Lino Polese, Imerio Angriman, Marco Scarpa, Lorenzo Norberto, Giacomo Carlo Sturniolo, Attilio Cecchetto, Cesare Ruffolo, Davide Francesco D'Amico

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We analyse the costimulating role of CD40/CD40 ligand and B7/CD28 in inflammatory bowel diseases (IBD) as a potential target of antibody therapy. CD40, expressed by lamina propria B lymphocytes in gut mucosa, interacts with CD40 ligand on T cell. This interaction is implicated in the pathogenesis of IBD. In some animal models of colitis the anti-CD40L therapy demonstrated to be effective. Phase II trials on Crohn's disease are ongoing. B7.1 and B7.2, expressed by macrophages, interact with CD28, on T cell. B7.2 resulted implicated in ulcerative colitis, determining a Th2 pattern, whereas B7.1, a major Th1 stimulator, could be involved in Crohn's disease. In some animal models of colitis anti-B7.1, but not anti-B7.2, was effective. Anti B7 therapy was not yet tested in humans.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalActa Biomedica
Volume74
Issue numberSUPPL. 2
Publication statusPublished - 2003

Fingerprint

CD40 Ligand
Inflammatory Bowel Diseases
Colitis
Crohn Disease
Mucous Membrane
Animal Models
T-Lymphocytes
Ulcerative Colitis
B-Lymphocytes
Therapeutics
Macrophages
Antibodies

Keywords

  • CD40
  • Crohn's disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Polese, L., Angriman, I., Scarpa, M., Norberto, L., Sturniolo, G. C., Cecchetto, A., ... D'Amico, D. F. (2003). Role of CD40 and B7 costimulators in inflammatory bowel diseases. Acta Biomedica, 74(SUPPL. 2), 65-70.

Role of CD40 and B7 costimulators in inflammatory bowel diseases. / Polese, Lino; Angriman, Imerio; Scarpa, Marco; Norberto, Lorenzo; Sturniolo, Giacomo Carlo; Cecchetto, Attilio; Ruffolo, Cesare; D'Amico, Davide Francesco.

In: Acta Biomedica, Vol. 74, No. SUPPL. 2, 2003, p. 65-70.

Research output: Contribution to journalArticle

Polese, L, Angriman, I, Scarpa, M, Norberto, L, Sturniolo, GC, Cecchetto, A, Ruffolo, C & D'Amico, DF 2003, 'Role of CD40 and B7 costimulators in inflammatory bowel diseases', Acta Biomedica, vol. 74, no. SUPPL. 2, pp. 65-70.
Polese L, Angriman I, Scarpa M, Norberto L, Sturniolo GC, Cecchetto A et al. Role of CD40 and B7 costimulators in inflammatory bowel diseases. Acta Biomedica. 2003;74(SUPPL. 2):65-70.
Polese, Lino ; Angriman, Imerio ; Scarpa, Marco ; Norberto, Lorenzo ; Sturniolo, Giacomo Carlo ; Cecchetto, Attilio ; Ruffolo, Cesare ; D'Amico, Davide Francesco. / Role of CD40 and B7 costimulators in inflammatory bowel diseases. In: Acta Biomedica. 2003 ; Vol. 74, No. SUPPL. 2. pp. 65-70.
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