TY - JOUR
T1 - Role of cellular immunity in the pathogenesis of autoimmune skin diseases
AU - Alaibac, M.
AU - Berti, E.
AU - Chizzolini, C.
AU - Fineschi, S.
AU - Marzano, A. V.
AU - Pigozzi, B.
AU - Riboldi, E.
AU - Sozzani, S.
AU - Kuhn, Annegret
PY - 2006/1
Y1 - 2006/1
N2 - The pathomechanism of most autoimmune skin diseases is still elusive; however, recent clinical and basic research is leading novel insights into the cellular and molecular biological underlying pathways. Several types of infectious skin diseases are infiltrated by significant number of γ/δ T cells and similar observations have been made in selected immune-mediated skin conditions. In particular, a role for γ/δ T cells has been suggested in discoid lupus erythematosus, contact dermatitis, herpetiformis dermatitis, necrotizing cutaneous vasculitis, and cutaneous lesions of systemic sclerosis. The pathogenesis of these diseases is different and this may suggest multiple potential functions of this subset of T cells in the immune system of the skin. Furthermore, most T cells infiltrating tissue and organs undergoing fibrosis have the potential to produce high levels of interleukin 4. This is particularly true for the CD8+ or CD4+ CD8+ double positive T-cell subsets. Furthermore, leukocyte recruitment is a key event in immunity and a better understanding of the signals involved in autoimmune diseases constitutes a valuable basis for the development of new strategies, which control leukocyte migration and function under pathological conditions.
AB - The pathomechanism of most autoimmune skin diseases is still elusive; however, recent clinical and basic research is leading novel insights into the cellular and molecular biological underlying pathways. Several types of infectious skin diseases are infiltrated by significant number of γ/δ T cells and similar observations have been made in selected immune-mediated skin conditions. In particular, a role for γ/δ T cells has been suggested in discoid lupus erythematosus, contact dermatitis, herpetiformis dermatitis, necrotizing cutaneous vasculitis, and cutaneous lesions of systemic sclerosis. The pathogenesis of these diseases is different and this may suggest multiple potential functions of this subset of T cells in the immune system of the skin. Furthermore, most T cells infiltrating tissue and organs undergoing fibrosis have the potential to produce high levels of interleukin 4. This is particularly true for the CD8+ or CD4+ CD8+ double positive T-cell subsets. Furthermore, leukocyte recruitment is a key event in immunity and a better understanding of the signals involved in autoimmune diseases constitutes a valuable basis for the development of new strategies, which control leukocyte migration and function under pathological conditions.
KW - γ/δ t-cells
KW - Autoimmune skin diseases
KW - Leukocyte recruitment
KW - Pathophysiologic mechanism
KW - Systemic sclerosis
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M3 - Article
C2 - 16466620
AN - SCOPUS:33645029714
VL - 24
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - SUPPL. 40
ER -