Ruolo delle chemochine nella patogenesi della sinovite cronica in corso di artrite reumatoide.

Translated title of the contribution: Role of chemokines in the pathogenesis of chronic synovitis during rheumatoid arthritis

F. Ingegnoli, A. Manzo, F. Fantini, R. Caporali, C. Montecucco, N. Pipitone, C. Pitzalis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chemokines play a central role in the pathogenesis of rheumatoid arthritis (RA) synovitis which is characterised by new blood vessel formation, thickening of the lining layer and infiltration of immune cells. The inflammatory infiltrate is generated by a series of events which include the recruitment of leukocytes from the blood stream into the tissue, their local retention and activation to effector cells. All these processes are finely regulated by the interplay of different cell adhesion molecules (CAMs) and chemoattractant factors called chemokines (CK). CK are a superfamily of small proteins that play a crucial role in immune and inflammatory reactions. These chemoattractant cytokines share structural similarities including four conserved cysteine residues which form disulphide bonds in the tertiary structure of the proteins. CK mediate their effects by binding specific receptors (CK-R) characterised by a domain structure which spans the cell membrane seven times and signal through heterotrimeric GPT-binding proteins. Activation of the CK network results in an amplification of the inflammatory cascade and consequently in the progressive destruction of RA joints. The recognition of the central role of CK in inflammation has paved the way to the development of new agents capable of interfering with CK and CK-R. This review will focus in particular on the role of CK in regulating leukocyte trafficking in RA joints.

Original languageItalian
Pages (from-to)12-18
Number of pages7
JournalReumatismo
Volume54
Issue number1
Publication statusPublished - 2002

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Synovitis
Chemokines
Rheumatoid Arthritis
Chemotactic Factors
Leukocytes
Joints
Chemokine Receptors
Cell Adhesion Molecules
Tertiary Protein Structure
Disulfides
Cysteine
Blood Vessels
Carrier Proteins
Cell Membrane
Cytokines
Inflammation

ASJC Scopus subject areas

  • Rheumatology

Cite this

Ingegnoli, F., Manzo, A., Fantini, F., Caporali, R., Montecucco, C., Pipitone, N., & Pitzalis, C. (2002). Ruolo delle chemochine nella patogenesi della sinovite cronica in corso di artrite reumatoide. Reumatismo, 54(1), 12-18.

Ruolo delle chemochine nella patogenesi della sinovite cronica in corso di artrite reumatoide. / Ingegnoli, F.; Manzo, A.; Fantini, F.; Caporali, R.; Montecucco, C.; Pipitone, N.; Pitzalis, C.

In: Reumatismo, Vol. 54, No. 1, 2002, p. 12-18.

Research output: Contribution to journalArticle

Ingegnoli, F, Manzo, A, Fantini, F, Caporali, R, Montecucco, C, Pipitone, N & Pitzalis, C 2002, 'Ruolo delle chemochine nella patogenesi della sinovite cronica in corso di artrite reumatoide.', Reumatismo, vol. 54, no. 1, pp. 12-18.
Ingegnoli, F. ; Manzo, A. ; Fantini, F. ; Caporali, R. ; Montecucco, C. ; Pipitone, N. ; Pitzalis, C. / Ruolo delle chemochine nella patogenesi della sinovite cronica in corso di artrite reumatoide. In: Reumatismo. 2002 ; Vol. 54, No. 1. pp. 12-18.
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