Role of chemotherapy and GM-CSF on hemopoietic progenitor cell mobilization in multiple myeloma

C. Tarella, M. Boccadoro, P. Omede, P. Bondesan, D. Caracciolo, R. Frieri, M. Bregni, S. Siena, A. M. Gianni, A. Pileri

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Abstract

Circulating hemopoietic progenitors were evaluated in 19 multiple myeloma patients at diagnosis. Eleven patients received either high-dose cyclophosphamide (7g/m2, 8 patients) or etoposide (2g/m2, 3 patients) followed by GM-CSF administration; the remaining 8 patients received intermediate-dose cyclophosphamide (1.2g/m2 on days 1 and 3), 4 of them with GM-CSF support. The highest levels of circulating progenitor cells were observed among patients in the high-dose chemotherapy group (median CFU-GM peak value of 6432 per ml), while in patients receiving intermediate-dose, with or without GM-CSF, median peak values were 2588 and 462 per ml, respectively. In all groups a remarkable heterogeneity in the yield of circulating progenitors was observed; this was particularly pronounced in the high-dose group, where CFU-GM peak values ranged between 200 and 38 070 per ml. At variance with the effect observed in previously untreated patients with lymphoma or breast cancer, the degree of mobilization in myeloma patients was rather unpredictable. The only pre-treatment characteristic correlating to some extent with a poor expansion of the circulating progenitor pool was heavy BM infiltration with plasma cells. The mobilizing effect was not restricted to the myeloid lineage, as demonstrated by the rise of BFU-E; CD34+ cells were increased as well. Indeed, a simultaneous evaluation of CFU-GM and CD34+ cells was carried out and a highly significant correlation (r=0.9) was observed. Owing to the marked and unpredictable variability observed, a real time test such as CD34 analysis of circulating blood cells is therefore recommended in multiple myeloma, to help in the selection of patients with a number of circulating hemopoietic cells adequate for large scale collection by leukapheresis.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalBone Marrow Transplantation
Volume11
Issue number4
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Tarella, C., Boccadoro, M., Omede, P., Bondesan, P., Caracciolo, D., Frieri, R., Bregni, M., Siena, S., Gianni, A. M., & Pileri, A. (1993). Role of chemotherapy and GM-CSF on hemopoietic progenitor cell mobilization in multiple myeloma. Bone Marrow Transplantation, 11(4), 271-277.