Role of chemotherapy in the management of vulvar carcinoma

Federica Tomao, Chiara Di Tucci, Claudia Marchetti, Giorgia Perniola, Filippo Bellati, Pierluigi Benedetti Panici

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aim of this review is to evaluate the use of chemotherapy (CT) in the treatment of squamous vulvar cancer. Since the 90s there was a continuous evolution in the therapeutic approach to this tumour. Although primary surgery is now considered the most effective approach, there are advanced diseases in which surgery may compromise anatomical structures causing severe mutilation. These are the reasons why CHT, with or without concomitant radiotherapy RT, started to be strongly recommended as neoadjuvant strategy. Chemotherapeutic agents have also been used alone as adjuvant treatment or in association with RT, by exploiting the radiosensitizing effect of these drugs. There are few data about the use of CHT as palliative treatment but recent studies point to the use of target therapy. In conclusion, clinical data and the evidence of chemo-sensitivity in vulvar squamous cell carcinoma open new possibilities to future research in this field.

Original languageEnglish
Pages (from-to)25-39
Number of pages15
JournalCritical Reviews in Oncology/Hematology
Volume82
Issue number1
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Radiation-Sensitizing Agents
Carcinoma
Drug Therapy
Vulvar Neoplasms
Therapeutics
Palliative Care
Squamous Cell Carcinoma
Radiotherapy
Neoplasms

Keywords

  • Chemotherapy
  • Squamous vulvar cancer

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

Cite this

Tomao, F., Di Tucci, C., Marchetti, C., Perniola, G., Bellati, F., & Panici, P. B. (2012). Role of chemotherapy in the management of vulvar carcinoma. Critical Reviews in Oncology/Hematology, 82(1), 25-39. https://doi.org/10.1016/j.critrevonc.2011.04.008

Role of chemotherapy in the management of vulvar carcinoma. / Tomao, Federica; Di Tucci, Chiara; Marchetti, Claudia; Perniola, Giorgia; Bellati, Filippo; Panici, Pierluigi Benedetti.

In: Critical Reviews in Oncology/Hematology, Vol. 82, No. 1, 04.2012, p. 25-39.

Research output: Contribution to journalArticle

Tomao, F, Di Tucci, C, Marchetti, C, Perniola, G, Bellati, F & Panici, PB 2012, 'Role of chemotherapy in the management of vulvar carcinoma', Critical Reviews in Oncology/Hematology, vol. 82, no. 1, pp. 25-39. https://doi.org/10.1016/j.critrevonc.2011.04.008
Tomao, Federica ; Di Tucci, Chiara ; Marchetti, Claudia ; Perniola, Giorgia ; Bellati, Filippo ; Panici, Pierluigi Benedetti. / Role of chemotherapy in the management of vulvar carcinoma. In: Critical Reviews in Oncology/Hematology. 2012 ; Vol. 82, No. 1. pp. 25-39.
@article{1ce22da3af8245d8a91aecb541454ccf,
title = "Role of chemotherapy in the management of vulvar carcinoma",
abstract = "The aim of this review is to evaluate the use of chemotherapy (CT) in the treatment of squamous vulvar cancer. Since the 90s there was a continuous evolution in the therapeutic approach to this tumour. Although primary surgery is now considered the most effective approach, there are advanced diseases in which surgery may compromise anatomical structures causing severe mutilation. These are the reasons why CHT, with or without concomitant radiotherapy RT, started to be strongly recommended as neoadjuvant strategy. Chemotherapeutic agents have also been used alone as adjuvant treatment or in association with RT, by exploiting the radiosensitizing effect of these drugs. There are few data about the use of CHT as palliative treatment but recent studies point to the use of target therapy. In conclusion, clinical data and the evidence of chemo-sensitivity in vulvar squamous cell carcinoma open new possibilities to future research in this field.",
keywords = "Chemotherapy, Squamous vulvar cancer",
author = "Federica Tomao and {Di Tucci}, Chiara and Claudia Marchetti and Giorgia Perniola and Filippo Bellati and Panici, {Pierluigi Benedetti}",
year = "2012",
month = "4",
doi = "10.1016/j.critrevonc.2011.04.008",
language = "English",
volume = "82",
pages = "25--39",
journal = "Critical Reviews in Oncology/Hematology",
issn = "1040-8428",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Role of chemotherapy in the management of vulvar carcinoma

AU - Tomao, Federica

AU - Di Tucci, Chiara

AU - Marchetti, Claudia

AU - Perniola, Giorgia

AU - Bellati, Filippo

AU - Panici, Pierluigi Benedetti

PY - 2012/4

Y1 - 2012/4

N2 - The aim of this review is to evaluate the use of chemotherapy (CT) in the treatment of squamous vulvar cancer. Since the 90s there was a continuous evolution in the therapeutic approach to this tumour. Although primary surgery is now considered the most effective approach, there are advanced diseases in which surgery may compromise anatomical structures causing severe mutilation. These are the reasons why CHT, with or without concomitant radiotherapy RT, started to be strongly recommended as neoadjuvant strategy. Chemotherapeutic agents have also been used alone as adjuvant treatment or in association with RT, by exploiting the radiosensitizing effect of these drugs. There are few data about the use of CHT as palliative treatment but recent studies point to the use of target therapy. In conclusion, clinical data and the evidence of chemo-sensitivity in vulvar squamous cell carcinoma open new possibilities to future research in this field.

AB - The aim of this review is to evaluate the use of chemotherapy (CT) in the treatment of squamous vulvar cancer. Since the 90s there was a continuous evolution in the therapeutic approach to this tumour. Although primary surgery is now considered the most effective approach, there are advanced diseases in which surgery may compromise anatomical structures causing severe mutilation. These are the reasons why CHT, with or without concomitant radiotherapy RT, started to be strongly recommended as neoadjuvant strategy. Chemotherapeutic agents have also been used alone as adjuvant treatment or in association with RT, by exploiting the radiosensitizing effect of these drugs. There are few data about the use of CHT as palliative treatment but recent studies point to the use of target therapy. In conclusion, clinical data and the evidence of chemo-sensitivity in vulvar squamous cell carcinoma open new possibilities to future research in this field.

KW - Chemotherapy

KW - Squamous vulvar cancer

UR - http://www.scopus.com/inward/record.url?scp=84858761517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858761517&partnerID=8YFLogxK

U2 - 10.1016/j.critrevonc.2011.04.008

DO - 10.1016/j.critrevonc.2011.04.008

M3 - Article

VL - 82

SP - 25

EP - 39

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

SN - 1040-8428

IS - 1

ER -