Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin

William Vermi, Elena Riboldi, Valerie Wittamer, Francesca Gentili, Walter Luini, Simona Marrelli, Annunciata Vecchi, Jean Denis Franssen, David Communi, Luisa Massardi, Marina Sironi, Alberto Mantovani, Marc Parmentier, Fabio Facchetti, Silvano Sozzani

Research output: Contribution to journalArticlepeer-review

Abstract

Chemerin is a chemotactic agent that was recently identified as the ligand of ChemR23, a serpentine receptor expressed by activated macrophages and monocyte-derived dendritic cells (DCs). This paper shows that blood plasmacytoid and myeloid DCs express functional ChemR23. Recombinant chemerin induced the transmigration of plasmacytoid and myeloid DCs across an endothelial cell monolayer. In secondary lymphoid organs (lymph nodes and tonsils), ChemR23 is expressed by CD123+ plasmacytoid DCs and by CD1a+ DC-SIGN+ DCs in the interfollicular T cell area. ChemR23+ DCs were also observed in dermis from normal skin, whereas Langerhans cells were negative. Chemerin expression was selectively detected on the luminal side of high endothelial venules in secondary lymphoid organs and in dermal endothelial vessels of lupus erythematosus skin lesions. Chemerin+ endothelial cells were surrounded by ChemR23+ plasmacytoid DCs. Thus, ChemR23 is expressed and functional in plasmacytoid DCs, a property shared only by CXCR4 among chemotactic receptors. This finding, together with the selective expression of the cognate ligand on the luminal side of high endothelial venules and inflamed endothelium, suggests a key role of the ChemR23/chemerin axis in directing plasmacytoid DC trafficking.

Original languageEnglish
Pages (from-to)509-515
Number of pages7
JournalJournal of Experimental Medicine
Volume201
Issue number4
DOIs
Publication statusPublished - Feb 21 2005

ASJC Scopus subject areas

  • Immunology

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