Role of citron kinase in dendritic morphogenesis of cortical neurons

Ferdinando Di Cunto, Luciana Ferrara, Roberta Curtetti, Sara Imarisio, Simona Guazzone, Vania Broccoli, Alessandro Bulfone, Fiorella Altruda, Alessandro Vercelli, Lorenzo Silengo

Research output: Contribution to journalArticlepeer-review

Abstract

Small GTPases of the rho family regulate the extensive rearrangements of the cytoskeleton that characterize neuronal differentiation. Citron kinase is a target molecule for activated rhoA, previously implicated in control of cytokinesis. We have found that, in addition, it could play an important role in modulating the extension of neuronal processes. Using constitutively active and dominant negative mutants, we showed that citron kinase is involved in the morphologic differentiation of N1E-115 neuroblastoma cells induced by serum starvation. More importantly, quantitative analysis of citron kinase knockout cerebral cortex displayed that this molecule may differentially regulate the morphology of the dendritic compartment in corticocollicular versus callosally-projecting pyramidal neurons.

Original languageEnglish
Pages (from-to)319-327
Number of pages9
JournalBrain Research Bulletin
Volume60
Issue number4
DOIs
Publication statusPublished - May 30 2003

Keywords

  • Cytoskeleton
  • Development
  • Differentiation
  • rho GTPases

ASJC Scopus subject areas

  • Neuroscience(all)

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