Ruolo della farmacologia clinica nel monitoraggio della terapia in soggetti con infezione da HIV

Translated title of the contribution: Role of clinical pharmacology in monitoring AIDS therapies

Paola Villani, Laura Cocchi, Roberto Giacchino, Elena Seminari, Mario B. Regazzi, Renato Maserati

Research output: Contribution to journalArticle

Abstract

The number of subjects with HIV infection or full-blown Acquired Immunodeficiency Syndrome (AIDS) is increasing throughout the world and the range of related opportunistic conditions (infections, neoplasms or degenerative disorders) is also increasing. Consequently, AIDS patients are likely to be prescribed a greater number of different drugs. HIV infection is a progressive phenomenon, characterized by inevitable and often irreversible changes which may influence drug disposition, enhancing the risk of toxic adverse effects and drug interactions. One of the stages for the development of new agents and the establishment of an effective therapy is to conduct pharmacokinetic studies. Even though such studies are difficult to realize in AIDS subjects, the knowledge of altered pharmacokinetics of a drug in disease states offers an unique approach for improving and perhaps optimizing the therapeutic management. The purpose of this article is to review our current understanding of how HIV infection influences the various processes of drug disposition (i.e. absorption, distribution, metabolism and excretion).

Translated title of the contributionRole of clinical pharmacology in monitoring AIDS therapies
Original languageItalian
Pages (from-to)279-293
Number of pages15
JournalClinica Terapeutica
Volume147
Issue number6
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Medicine(all)

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