Role of common-gamma chain cytokines in NK cell development and function

Perspectives for immunotherapy

Silvano Ferrini, Raffaella Meazza, Bruno Azzarone, Anna Maria Orengo

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

NK cells are components of the innate immunity system and play an important role as a first-line defense mechanism against viral infections and in tumor immune surveillance. Their development and their functional activities are controlled by several factors among which cytokines sharing the usage of the common cytokine-receptor gamma chain play a pivotal role. In particular, IL-2, IL-7, IL-15, and IL-21 are the members of this family predominantly involved in NK cell biology. In this paper, we will address their role in NK cell ontogeny, regulation of functional activities, development of specialized cell subsets, and acquisition of memory-like functions. Finally, the potential application of these cytokines as recombinant molecules to NK cell-based immunotherapy approaches will be discussed.

Original languageEnglish
Article number861920
JournalJournal of Biomedicine and Biotechnology
Volume2011
DOIs
Publication statusPublished - 2011

Fingerprint

Natural Killer Cells
Immunotherapy
Cytokines
Interleukin Receptor Common gamma Subunit
Interleukin-15
Interleukin-7
Virus Diseases
Defense Mechanisms
Cellular Structures
Innate Immunity
Interleukin-2
Cell Biology
Neoplasms

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Role of common-gamma chain cytokines in NK cell development and function : Perspectives for immunotherapy. / Ferrini, Silvano; Meazza, Raffaella; Azzarone, Bruno; Orengo, Anna Maria.

In: Journal of Biomedicine and Biotechnology, Vol. 2011, 861920, 2011.

Research output: Contribution to journalArticle

@article{174f446e5c2a46d6b16200f346f082c7,
title = "Role of common-gamma chain cytokines in NK cell development and function: Perspectives for immunotherapy",
abstract = "NK cells are components of the innate immunity system and play an important role as a first-line defense mechanism against viral infections and in tumor immune surveillance. Their development and their functional activities are controlled by several factors among which cytokines sharing the usage of the common cytokine-receptor gamma chain play a pivotal role. In particular, IL-2, IL-7, IL-15, and IL-21 are the members of this family predominantly involved in NK cell biology. In this paper, we will address their role in NK cell ontogeny, regulation of functional activities, development of specialized cell subsets, and acquisition of memory-like functions. Finally, the potential application of these cytokines as recombinant molecules to NK cell-based immunotherapy approaches will be discussed.",
author = "Silvano Ferrini and Raffaella Meazza and Bruno Azzarone and Orengo, {Anna Maria}",
year = "2011",
doi = "10.1155/2011/861920",
language = "English",
volume = "2011",
journal = "Journal of Biomedicine and Biotechnology",
issn = "1110-7243",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Role of common-gamma chain cytokines in NK cell development and function

T2 - Perspectives for immunotherapy

AU - Ferrini, Silvano

AU - Meazza, Raffaella

AU - Azzarone, Bruno

AU - Orengo, Anna Maria

PY - 2011

Y1 - 2011

N2 - NK cells are components of the innate immunity system and play an important role as a first-line defense mechanism against viral infections and in tumor immune surveillance. Their development and their functional activities are controlled by several factors among which cytokines sharing the usage of the common cytokine-receptor gamma chain play a pivotal role. In particular, IL-2, IL-7, IL-15, and IL-21 are the members of this family predominantly involved in NK cell biology. In this paper, we will address their role in NK cell ontogeny, regulation of functional activities, development of specialized cell subsets, and acquisition of memory-like functions. Finally, the potential application of these cytokines as recombinant molecules to NK cell-based immunotherapy approaches will be discussed.

AB - NK cells are components of the innate immunity system and play an important role as a first-line defense mechanism against viral infections and in tumor immune surveillance. Their development and their functional activities are controlled by several factors among which cytokines sharing the usage of the common cytokine-receptor gamma chain play a pivotal role. In particular, IL-2, IL-7, IL-15, and IL-21 are the members of this family predominantly involved in NK cell biology. In this paper, we will address their role in NK cell ontogeny, regulation of functional activities, development of specialized cell subsets, and acquisition of memory-like functions. Finally, the potential application of these cytokines as recombinant molecules to NK cell-based immunotherapy approaches will be discussed.

UR - http://www.scopus.com/inward/record.url?scp=80052661219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052661219&partnerID=8YFLogxK

U2 - 10.1155/2011/861920

DO - 10.1155/2011/861920

M3 - Article

VL - 2011

JO - Journal of Biomedicine and Biotechnology

JF - Journal of Biomedicine and Biotechnology

SN - 1110-7243

M1 - 861920

ER -