Role of copper in the onset of Alzheimer's disease compared to other metals

Soghra Bagheri, Rosanna Squitti, Thomas Haertlé, Mariacristina Siotto, Ali A. Saboury

Research output: Contribution to journalReview articlepeer-review

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and trace elements including Zn2+, Cu2+, and Fe2+. Some studies have shown that AD can be considered a type of metal dyshomeostasis. Among metal ions involved in plaques, numerous studies have focused on copper ions, which seem to be one of the main cationic elements in plaque formation. The involvement of copper in AD is controversial, as some studies show a copper deficiency in AD, and consequently a need to enhance copper levels, while other data point to copper overload and therefore a need to reduce copper levels. In this paper, the role of copper ions in AD and some contradictory reports are reviewed and discussed.

Original languageEnglish
Article number446
JournalFrontiers in Aging Neuroscience
Volume9
Issue numberJAN
DOIs
Publication statusPublished - Jan 23 2018

Keywords

  • Alzheimer's disease
  • Amyloid plaques
  • Calcium
  • Cholesterol
  • Copper
  • Neurodegenerative disorder
  • Zinc

ASJC Scopus subject areas

  • Ageing
  • Cognitive Neuroscience

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