Role of cytokines and chemokines in the regulation of innate immunity and HIV infection

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The earliest defense against microbial infection is represented by the responses of the innate (or natural) immune system, that also profoundly regulates the adaptive (or acquired) T- and B-cell immune responses. Activation of the innate immune system is primed by microbial invasion in response to conserved structures present in large groups of microorganisms (LPS, peptidoglycan, double-stranded RNA), and is finely tuned by different cell types (including dendritic cells, macrophages, natural killer cells, natural killer T cells, and γδ T cells). In addition, several soluble factors (complement components, defensins, mannose-binding lectins, interferons, cytokines and chemokines) can play a major role in the regulation of both the innate and adaptive immunity. In this review, we will briefly overview the regulation of some cellular subsets of the innate immune system particularly involved in human immunodeficiency virus (HIV) infection and then focus our attention on those cytokines and chemokines whose levels of expression are more profoundly affected by HIV infection and that, conversely, can modulate virus infection and replication.

Original languageEnglish
Pages (from-to)161-182
Number of pages22
JournalMolecular Immunology
Volume42
Issue number2
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Virus Diseases
Chemokines
Innate Immunity
Immune System
HIV
Cytokines
Mannose-Binding Lectins
Defensins
Natural Killer T-Cells
Double-Stranded RNA
Peptidoglycan
Adaptive Immunity
Virus Replication
Natural Killer Cells
Dendritic Cells
Interferons
B-Lymphocytes
Macrophages
T-Lymphocytes
Infection

Keywords

  • Chemokines
  • Cytokines
  • HIV
  • Innate immunity

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Role of cytokines and chemokines in the regulation of innate immunity and HIV infection. / Alfano, Massimo; Poli, Guido.

In: Molecular Immunology, Vol. 42, No. 2, 02.2005, p. 161-182.

Research output: Contribution to journalArticle

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