Role of cytoskeletal elements in the retractile activity of human skin fibroblasts

B. Azzarone, A. Macieira-Coelho

Research output: Contribution to journalArticle

Abstract

Giant axonal neuropathy skin fibroblasts, which are characterized by a selective and partial disorganization of vimentin filaments [1] exhibited, when compared with normal skin fibroblasts, less fibrin clot retractile (FCR) activity and spreading within the fibrin clot both during active growth and resting stage. Skin fibroblasts derived from patients affected with adenomatosis of the colon and rectum, which display a disorganized actin network [2], exhibited reduced FCR activity and spreading within the fibrin clot only during resting stage. FCR inhibition was also obtained by treating the cells with colcemid, cytochalasin B (CB) and dihydrocytochalasin B. The data suggest that FCR activity is under the control of different cytoskeletal structures. For the first time, a direct involvement of intermediatesized filaments could be demonstrated in the interaction between fibroblasts and an organic substratum.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalExperimental Cell Research
Volume155
Issue number1
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Role of cytoskeletal elements in the retractile activity of human skin fibroblasts'. Together they form a unique fingerprint.

  • Cite this