Abstract
The diagnosis of idiopathic Parkinson's disease (PD) can be achieved with high degrees of accuracy in cases with full expression of classical clinical features. However, diagnostic uncertainty remains in early disease with subtle or ambiguous signs. Functional imaging has been suggested to increase the diagnostic yield in parkinsonian syndromes with uncertain clinical classification. Loss of striatal dopamine nerve terminal function, a hallmark of neurodegenerative Parkinsonism, is strongly related to decreases of dopamine transporter (DAT) density, which can be measured by single photon emission computed tomography (SPECT). The use of DAT-SPECT facilitates the differential diagnosis in patients with isolated tremor symptoms not fulfilling PD or essential tremor criteria, drug-induced, psychogenic and vascular Parkinsonism as well as dementia when associated with Parkinsonism. This review addresses the value of DAT-SPECT in early differential diagnosis, and its potential as a screening tool for subjects at risk of developing PD as well as issues around the assessment of disease progression.
| Original language | English |
|---|---|
| Pages (from-to) | 1229-1238 |
| Number of pages | 10 |
| Journal | Movement Disorders |
| Volume | 22 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Jul 15 2007 |
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Keywords
- Differential diagnosis
- Dopamine transporter
- Parkinson's disease
- SPECT
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Role of DAT-SPECT in the diagnostic work up of Parkinsonism. / Scherfler, Christoph; Schwarz, Johannes; Antonini, Angelo; Grosset, Donald; Valldeoriola, Francesc; Marek, Kenneth; Oertel, Wolfgang; Tolosa, Eduardo; Lees, Andrew J.; Poewe, Werner.
In: Movement Disorders, Vol. 22, No. 9, 15.07.2007, p. 1229-1238.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of DAT-SPECT in the diagnostic work up of Parkinsonism
AU - Scherfler, Christoph
AU - Schwarz, Johannes
AU - Antonini, Angelo
AU - Grosset, Donald
AU - Valldeoriola, Francesc
AU - Marek, Kenneth
AU - Oertel, Wolfgang
AU - Tolosa, Eduardo
AU - Lees, Andrew J.
AU - Poewe, Werner
PY - 2007/7/15
Y1 - 2007/7/15
N2 - The diagnosis of idiopathic Parkinson's disease (PD) can be achieved with high degrees of accuracy in cases with full expression of classical clinical features. However, diagnostic uncertainty remains in early disease with subtle or ambiguous signs. Functional imaging has been suggested to increase the diagnostic yield in parkinsonian syndromes with uncertain clinical classification. Loss of striatal dopamine nerve terminal function, a hallmark of neurodegenerative Parkinsonism, is strongly related to decreases of dopamine transporter (DAT) density, which can be measured by single photon emission computed tomography (SPECT). The use of DAT-SPECT facilitates the differential diagnosis in patients with isolated tremor symptoms not fulfilling PD or essential tremor criteria, drug-induced, psychogenic and vascular Parkinsonism as well as dementia when associated with Parkinsonism. This review addresses the value of DAT-SPECT in early differential diagnosis, and its potential as a screening tool for subjects at risk of developing PD as well as issues around the assessment of disease progression.
AB - The diagnosis of idiopathic Parkinson's disease (PD) can be achieved with high degrees of accuracy in cases with full expression of classical clinical features. However, diagnostic uncertainty remains in early disease with subtle or ambiguous signs. Functional imaging has been suggested to increase the diagnostic yield in parkinsonian syndromes with uncertain clinical classification. Loss of striatal dopamine nerve terminal function, a hallmark of neurodegenerative Parkinsonism, is strongly related to decreases of dopamine transporter (DAT) density, which can be measured by single photon emission computed tomography (SPECT). The use of DAT-SPECT facilitates the differential diagnosis in patients with isolated tremor symptoms not fulfilling PD or essential tremor criteria, drug-induced, psychogenic and vascular Parkinsonism as well as dementia when associated with Parkinsonism. This review addresses the value of DAT-SPECT in early differential diagnosis, and its potential as a screening tool for subjects at risk of developing PD as well as issues around the assessment of disease progression.
KW - Differential diagnosis
KW - Dopamine transporter
KW - Parkinson's disease
KW - SPECT
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U2 - 10.1002/mds.21505
DO - 10.1002/mds.21505
M3 - Article
C2 - 17486648
AN - SCOPUS:34547659515
VL - 22
SP - 1229
EP - 1238
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 9
ER -