Role of DAT-SPECT in the diagnostic work up of Parkinsonism

Christoph Scherfler, Johannes Schwarz, Angelo Antonini, Donald Grosset, Francesc Valldeoriola, Kenneth Marek, Wolfgang Oertel, Eduardo Tolosa, Andrew J. Lees, Werner Poewe

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

The diagnosis of idiopathic Parkinson's disease (PD) can be achieved with high degrees of accuracy in cases with full expression of classical clinical features. However, diagnostic uncertainty remains in early disease with subtle or ambiguous signs. Functional imaging has been suggested to increase the diagnostic yield in parkinsonian syndromes with uncertain clinical classification. Loss of striatal dopamine nerve terminal function, a hallmark of neurodegenerative Parkinsonism, is strongly related to decreases of dopamine transporter (DAT) density, which can be measured by single photon emission computed tomography (SPECT). The use of DAT-SPECT facilitates the differential diagnosis in patients with isolated tremor symptoms not fulfilling PD or essential tremor criteria, drug-induced, psychogenic and vascular Parkinsonism as well as dementia when associated with Parkinsonism. This review addresses the value of DAT-SPECT in early differential diagnosis, and its potential as a screening tool for subjects at risk of developing PD as well as issues around the assessment of disease progression.

Original languageEnglish
Pages (from-to)1229-1238
Number of pages10
JournalMovement Disorders
Volume22
Issue number9
DOIs
Publication statusPublished - Jul 15 2007

Fingerprint

Dopamine Plasma Membrane Transport Proteins
Parkinsonian Disorders
Single-Photon Emission-Computed Tomography
Parkinson Disease
Differential Diagnosis
Essential Tremor
Corpus Striatum
Tremor
Uncertainty
Blood Vessels
Dementia
Disease Progression
Early Diagnosis
Dopamine
Pharmaceutical Preparations

Keywords

  • Differential diagnosis
  • Dopamine transporter
  • Parkinson's disease
  • SPECT

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Scherfler, C., Schwarz, J., Antonini, A., Grosset, D., Valldeoriola, F., Marek, K., ... Poewe, W. (2007). Role of DAT-SPECT in the diagnostic work up of Parkinsonism. Movement Disorders, 22(9), 1229-1238. https://doi.org/10.1002/mds.21505

Role of DAT-SPECT in the diagnostic work up of Parkinsonism. / Scherfler, Christoph; Schwarz, Johannes; Antonini, Angelo; Grosset, Donald; Valldeoriola, Francesc; Marek, Kenneth; Oertel, Wolfgang; Tolosa, Eduardo; Lees, Andrew J.; Poewe, Werner.

In: Movement Disorders, Vol. 22, No. 9, 15.07.2007, p. 1229-1238.

Research output: Contribution to journalArticle

Scherfler, C, Schwarz, J, Antonini, A, Grosset, D, Valldeoriola, F, Marek, K, Oertel, W, Tolosa, E, Lees, AJ & Poewe, W 2007, 'Role of DAT-SPECT in the diagnostic work up of Parkinsonism', Movement Disorders, vol. 22, no. 9, pp. 1229-1238. https://doi.org/10.1002/mds.21505
Scherfler C, Schwarz J, Antonini A, Grosset D, Valldeoriola F, Marek K et al. Role of DAT-SPECT in the diagnostic work up of Parkinsonism. Movement Disorders. 2007 Jul 15;22(9):1229-1238. https://doi.org/10.1002/mds.21505
Scherfler, Christoph ; Schwarz, Johannes ; Antonini, Angelo ; Grosset, Donald ; Valldeoriola, Francesc ; Marek, Kenneth ; Oertel, Wolfgang ; Tolosa, Eduardo ; Lees, Andrew J. ; Poewe, Werner. / Role of DAT-SPECT in the diagnostic work up of Parkinsonism. In: Movement Disorders. 2007 ; Vol. 22, No. 9. pp. 1229-1238.
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