An anesthesiological-surgical protocol using dexamethasone-21-phosphate before, during and after surgical procedure was begun in February 1976. Doses of the drug were calculated according to patient request and to type of planned surgery (high doses in biopsy or partial tumor removal, standard doses in total or subtotal removal). Preoperative and prolonged use of dexamethasone permits adequate drug levels and eliminates the lapse between drug administration and its effectiveness and quickly allows the dose to be adjusted to the level required by the patient's conditions during surgery and postoperative period. In comparison with 96 control patients, the 128 treated patients withstood surgery better, were more resistant to surgical trauma and therefore had a better postoperative recovery.
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