Role of Dietary and Endogenous Antioxidants in Diabetes

Giuseppina Marrazzo, Ignazio Barbagallo, Fabio Galvano, Michele Malaguarnera, Diego Gazzolo, Alessandro Frigiola, Nicolantonio D'Orazio, Giovanni Li Volti

Research output: Contribution to journalArticlepeer-review


Diabetes affects different people of all ages, race, and sex. This is a condition characterized by a state of chronic hyperglycaemia that leads to an increase of intracellular oxidative stress linked to the overproduction of free radicals. In the present review, we focus our attention on the molecular mechanisms leading to oxidative stress-mediates complications with particular regard to central nervous system (CNS). Furthermore, the present review reports the effects of different kind of antioxidants with enzymatic and nonenzymatic action that may significantly decrease the intracellular free radicals' overproduction and prevents the hyperglycaemia-mediated complications.

Original languageEnglish
Pages (from-to)1599-1616
Number of pages18
JournalCritical Reviews in Food Science and Nutrition
Issue number12
Publication statusPublished - Dec 2014


  • Antioxidants
  • central nervous system
  • Diabetes
  • diet

ASJC Scopus subject areas

  • Food Science
  • Industrial and Manufacturing Engineering


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