Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma

F. Ferrara, L. De Santis, F. Mangili, I. Sassi, S. Luchini, C. Mandelli, G. Santambrogio, A. Cantaboni

Research output: Contribution to journalArticle

Abstract

Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper. Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.

Original languageEnglish
Pages (from-to)1039-1043
Number of pages5
JournalPathology Research and Practice
Volume190
Issue number11
Publication statusPublished - 1994

Keywords

  • DNA ploidy
  • Endometrial carcinoma
  • ERB-B2 overexpression
  • Immunohistochemistry
  • Oncogene

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Ferrara, F., De Santis, L., Mangili, F., Sassi, I., Luchini, S., Mandelli, C., Santambrogio, G., & Cantaboni, A. (1994). Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma. Pathology Research and Practice, 190(11), 1039-1043.