Role of dopamine D-1 and D-2 antagonists in a model of focal epilepsy induced by electrical stimulation of hippocampus and amygdala in the rabbit

Paola Bo, Debora Soragna, Enrico Marchioni, Elisa Candeloro, Andrea Albergati, Faustino Savoldi

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. The differential role played by blockade of D-1 or D-2 dopamine receptors in mechanisms underlying seizures was studied in a model of EEG after-discharge induced by electrical stimulation of selective brain regions (dorsal hippocampus and amygdala) in the rabbit. 2. 2. The D-2 antagonist haloperidol (1 mg/Kg) increased significantly after-discharge duration after stimulation of either hippocampus or amygdala and lowered after-discharge threshold in few animals. 3. 3. The D-1 antagonist SCH 23390 (0.3 mg/Kg) caused no changes following stimulation of amygdala and reduced after-discharge duration when hippocampus was stimulated. 4. 4. Haloperidol exerted a proconvulsant action in this experimental model, having a clearer influence on D-2 receptors. SCH 23390 had no effect on amygdala whereas it exerted protection on the hippocampus. 5. 5. The present data suggest that D-1 and D-2 receptors have different roles in generating and spreading the epileptic activity.

Original languageEnglish
Pages (from-to)917-930
Number of pages14
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume19
Issue number5
DOIs
Publication statusPublished - 1995

Keywords

  • D-1 and D-2 receptors
  • Dopamine
  • epilepsy
  • rabbits

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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