Role of dopamine receptors in the short- and long-term regulation of corticostriatal transmission

Research output: Contribution to journalArticlepeer-review

Abstract

Several studies have tried to clarify the role of different dopamine (DA) receptors in the control of membrane excitability of striatal neurons. Activation of DA receptors influences both synaptic and intrinsic membrane properties of striatal neurons. More recently it has been reported that endogenous DA plays an important role in the expression of striatal synaptic plasticity. In this review we will try to summarize and discuss the available data concerning the possible impact of the functional role of D1 and D2 receptor activation on the short and tong-term modulation of the excitatory glutamatergic corticostriatal transmission. Moreover, we will also describe the function of the striatum in the integration of glutamatergic and DAergic inputs to produce long-term changes of synaptic efficacy: long-term depression (LTD) and long-term potentiation (LTP).

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalJapanese Journal of Psychopharmacology
Volume17
Issue number2
Publication statusPublished - 1997

Keywords

  • Dopamine
  • Excitatory amino acids
  • Striatum
  • Synaptic plasticity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Role of dopamine receptors in the short- and long-term regulation of corticostriatal transmission'. Together they form a unique fingerprint.

Cite this