Role of empirical and targeted therapy in hospitalized patients with bloodstream infections caused by ESBL-producing Enterobacteriaceae.

M. Falcone, A. Vena, M. L. Mezzatesta, F. Gona, C. Caio, P. Goldoni, A. M. Trancassini, C. Conti, G. B. Orsi, P. Carfagna, S. Stefani, M. Venditti

Research output: Contribution to journalArticle

Abstract

Bloodstream infection (BSI) due to extended-spectrum β-lactamase (ESBL) producing Enterobacteriaceae are a major cause of in-hospital mortality. The effect on survival of empirical and targeted antibiotic therapy in these patients remains controversial. A prospective cohort study was conducted analyzing data from 94 patients (age 59 ± 21 years) with BSI due to ESBL producing strains (Sixty-one E. coli, 26 K. pneumoniae, 4 Proteus spp and 3 Enterobacter spp). Risk factors associated with 21-day mortality at univariate analysis were: recent administration of antibiotic therapy (p=0.049), higher SOFA score (p=0.05), ICU stay (p

Original languageEnglish
Pages (from-to)293-304
Number of pages12
JournalAnnali di igiene : medicina preventiva e di comunità
Volume26
Issue number4
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Falcone, M., Vena, A., Mezzatesta, M. L., Gona, F., Caio, C., Goldoni, P., Trancassini, A. M., Conti, C., Orsi, G. B., Carfagna, P., Stefani, S., & Venditti, M. (2014). Role of empirical and targeted therapy in hospitalized patients with bloodstream infections caused by ESBL-producing Enterobacteriaceae. Annali di igiene : medicina preventiva e di comunità, 26(4), 293-304.