TY - JOUR
T1 - Role of endothelin-1 in exposure to high altitude
T2 - Acute mountain sickness and endothelin-1 (ACME-1) study
AU - Modesti, Pietro Amedeo
AU - Vanni, Simone
AU - Morabito, Marco
AU - Modesti, Alessandra
AU - Marchetta, Matilde
AU - Gamberi, Tania
AU - Sofi, Francesco
AU - Savia, Giulio
AU - Mancia, Giuseppe
AU - Gensini, Gian Franco
AU - Parati, Gianfranco
PY - 2006/9
Y1 - 2006/9
N2 - BACKGROUND - The degree of pulmonary hypertension in healthy subjects exposed to acute hypobaric hypoxia at high altitude was found to be related to increased plasma endothelin (ET)-1. The aim of the present study was to investigate the effects of ET-1 antagonism on pulmonary hypertension, renal water, and sodium balance under acute and prolonged exposure to high-altitude-associated hypoxia. METHODS AND RESULTS - In a double-blind fashion, healthy volunteers were randomly assigned to receive bosentan (62.5 mg for 1 day and 125 mg for the following 2 days; n=10) or placebo (n=10) at sea level and after rapid ascent to high altitude (4559 m). At sea level, bosentan did not induce any significant changes in hemodynamic or renal parameters. At altitude, bosentan induced a significant reduction of systolic pulmonary artery pressure (21±7 versus 31±7 mm Hg, P
AB - BACKGROUND - The degree of pulmonary hypertension in healthy subjects exposed to acute hypobaric hypoxia at high altitude was found to be related to increased plasma endothelin (ET)-1. The aim of the present study was to investigate the effects of ET-1 antagonism on pulmonary hypertension, renal water, and sodium balance under acute and prolonged exposure to high-altitude-associated hypoxia. METHODS AND RESULTS - In a double-blind fashion, healthy volunteers were randomly assigned to receive bosentan (62.5 mg for 1 day and 125 mg for the following 2 days; n=10) or placebo (n=10) at sea level and after rapid ascent to high altitude (4559 m). At sea level, bosentan did not induce any significant changes in hemodynamic or renal parameters. At altitude, bosentan induced a significant reduction of systolic pulmonary artery pressure (21±7 versus 31±7 mm Hg, P
KW - Altitude
KW - Endothelin
KW - Hypoxia
KW - Lung
KW - Oxygen
KW - Pressure
KW - Pulmonary heart disease
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U2 - 10.1161/CIRCULATIONAHA.105.605527
DO - 10.1161/CIRCULATIONAHA.105.605527
M3 - Article
C2 - 16982943
AN - SCOPUS:33749028972
VL - 114
SP - 1410
EP - 1416
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 13
ER -