Role of endothelin-1 in exposure to high altitude: Acute mountain sickness and endothelin-1 (ACME-1) study

Pietro Amedeo Modesti; Simone Vanni; Marco Morabito; Alessandra Modesti; Matilde Marchetta; Tania Gamberi; Francesco Sofi; Giulio Savia; Giuseppe Mancia; Gian Franco Gensini; Gianfranco Parati

doi:10.1161/CIRCULATIONAHA.105.605527

Role of endothelin-1 in exposure to high altitude: Acute mountain sickness and endothelin-1 (ACME-1) study

Pietro Amedeo Modesti, Simone Vanni, Marco Morabito, Alessandra Modesti, Matilde Marchetta, Tania Gamberi, Francesco Sofi, Giulio Savia, Giuseppe Mancia, Gian Franco Gensini, Gianfranco Parati

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND - The degree of pulmonary hypertension in healthy subjects exposed to acute hypobaric hypoxia at high altitude was found to be related to increased plasma endothelin (ET)-1. The aim of the present study was to investigate the effects of ET-1 antagonism on pulmonary hypertension, renal water, and sodium balance under acute and prolonged exposure to high-altitude-associated hypoxia. METHODS AND RESULTS - In a double-blind fashion, healthy volunteers were randomly assigned to receive bosentan (62.5 mg for 1 day and 125 mg for the following 2 days; n=10) or placebo (n=10) at sea level and after rapid ascent to high altitude (4559 m). At sea level, bosentan did not induce any significant changes in hemodynamic or renal parameters. At altitude, bosentan induced a significant reduction of systolic pulmonary artery pressure (21±7 versus 31±7 mm Hg, P

Original language	English
Pages (from-to)	1410-1416
Number of pages	7
Journal	Circulation
Volume	114
Issue number	13
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.105.605527
Publication status	Published - Sep 2006

Keywords

Altitude
Endothelin
Hypoxia
Lung
Oxygen
Pressure
Pulmonary heart disease

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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Role of endothelin-1 in exposure to high altitude : Acute mountain sickness and endothelin-1 (ACME-1) study. / Modesti, Pietro Amedeo; Vanni, Simone; Morabito, Marco; Modesti, Alessandra; Marchetta, Matilde; Gamberi, Tania; Sofi, Francesco; Savia, Giulio; Mancia, Giuseppe; Gensini, Gian Franco; Parati, Gianfranco.

In: Circulation, Vol. 114, No. 13, 09.2006, p. 1410-1416.

Research output: Contribution to journal › Article › peer-review

Modesti, Pietro Amedeo ; Vanni, Simone ; Morabito, Marco ; Modesti, Alessandra ; Marchetta, Matilde ; Gamberi, Tania ; Sofi, Francesco ; Savia, Giulio ; Mancia, Giuseppe ; Gensini, Gian Franco ; Parati, Gianfranco. / Role of endothelin-1 in exposure to high altitude : Acute mountain sickness and endothelin-1 (ACME-1) study. In: Circulation. 2006 ; Vol. 114, No. 13. pp. 1410-1416.

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abstract = "BACKGROUND - The degree of pulmonary hypertension in healthy subjects exposed to acute hypobaric hypoxia at high altitude was found to be related to increased plasma endothelin (ET)-1. The aim of the present study was to investigate the effects of ET-1 antagonism on pulmonary hypertension, renal water, and sodium balance under acute and prolonged exposure to high-altitude-associated hypoxia. METHODS AND RESULTS - In a double-blind fashion, healthy volunteers were randomly assigned to receive bosentan (62.5 mg for 1 day and 125 mg for the following 2 days; n=10) or placebo (n=10) at sea level and after rapid ascent to high altitude (4559 m). At sea level, bosentan did not induce any significant changes in hemodynamic or renal parameters. At altitude, bosentan induced a significant reduction of systolic pulmonary artery pressure (21±7 versus 31±7 mm Hg, P",

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AU - Morabito, Marco

AU - Modesti, Alessandra

AU - Marchetta, Matilde

AU - Gamberi, Tania

AU - Sofi, Francesco

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AU - Gensini, Gian Franco

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