Role of estrogen on bone in the human male: Insights from the natural models of congenital estrogen deficiency

Vincenzo Rochira, Antonio Balestrieri, Marco Faustini-Fustini, Cesare Carani

Research output: Contribution to journalArticle

Abstract

The reports of congenital estrogen deficiency - notably, estrogen resistance and aromatase deficiency - have completely changed our knowledge on the role of estrogen on bone in males. Particularly, the bone changes at puberty, which were classically considered androgen-dependent, are now considered to be induced at least in part by estrogen action. Clinical cases of congenital estrogen deficiency have clearly demonstrated that the role of estrogens in epiphyseal closure, skeletal proportions and bone mineralization is crucial not only in women but also in men. In addition progress have been made in the treatment of such a rare disease even though further studies are needed to a definitive understanding of this issue.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume178
Issue number1-2
DOIs
Publication statusPublished - Jun 19 2001

Keywords

  • Bone maturation
  • Bone mineralization
  • Estrogen deficiency
  • Estrogen replacement therapy
  • Eunuchoid skeleton
  • Male osteoporosis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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