TY - JOUR
T1 - Role of estrogens in inflammatory response
T2 - Expression of estrogen receptors in peritoneal fluid macrophages from endometriosis
AU - Capellino, Silvia
AU - Montagna, Paola
AU - Villaggio, Barbara
AU - Sulli, Alberto
AU - Soldano, Stefano
AU - Ferrero, Simone
AU - Remorgida, Valentino
AU - Cutolo, Maurizio
PY - 2006/6
Y1 - 2006/6
N2 - Estrogens are involved in the immune response, and macrophages express estrogen receptors (ER). Moreover, macrophages are the predominant cell type in the peritoneal fluid from endometriosis patients. On this basis, the aim of our study was to evaluate the expression of ER on peritoneal macrophages from endometriosis patients and to compare these results with what is already known about ER and macrophages in RA. After macrophage extraction from peritoneal fluids we performed the immunohistochemical localization of ERα and ERβ and then the image analysis. We found that both ERs were significantly overexpressed in macrophages of women with endometriosis compared with controls. These results suggest that estrogens, through their functional receptors, might modulate the immune response at least on macrophages. Therefore, estrogens seem to play an important role in the immune response, independently from the pathology.
AB - Estrogens are involved in the immune response, and macrophages express estrogen receptors (ER). Moreover, macrophages are the predominant cell type in the peritoneal fluid from endometriosis patients. On this basis, the aim of our study was to evaluate the expression of ER on peritoneal macrophages from endometriosis patients and to compare these results with what is already known about ER and macrophages in RA. After macrophage extraction from peritoneal fluids we performed the immunohistochemical localization of ERα and ERβ and then the image analysis. We found that both ERs were significantly overexpressed in macrophages of women with endometriosis compared with controls. These results suggest that estrogens, through their functional receptors, might modulate the immune response at least on macrophages. Therefore, estrogens seem to play an important role in the immune response, independently from the pathology.
KW - Endometriosis
KW - Estrogen receptors
KW - Estrogens
KW - Macrophages
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=33745593029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745593029&partnerID=8YFLogxK
U2 - 10.1196/annals.1351.024
DO - 10.1196/annals.1351.024
M3 - Article
C2 - 16855153
AN - SCOPUS:33745593029
VL - 1069
SP - 263
EP - 267
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -