Abstract
Invasive urinary tumors are relatively rare and their treatment may cause important changes in urinary, sexual, and social functions. A systematic review of external radiation therapy studies in urinary cancers has been carried out. This synthesis of the literature is based on data from meta-analysis, randomized and prospective trials, and retrospective studies. There are few controlled clinical trials using adjuvant or radical radiotherapy ± chemotherapy in kidney, ureter, and urethra cancers; there are several reports of muscle-invasive bladder cancer using multimodality treatment: intravesical surgery and neo-adjuvant chemotherapy to radiotherapy or concomitant radiochemotherapy with organ preservation. The conclusions reached for renal cancer are controversial; urethra and ureter cancers data are few and inconclusive; sufficient data now exist in literature to demonstrate that conservative management with organ preservation, for muscle-invasive bladder cancer, is a valid alternative to radical cystectomy, viewed as the gold standard.
| Original language | English |
|---|---|
| Journal | Annals of Oncology |
| Volume | 18 |
| Issue number | SUPPL. 6 |
| DOIs | |
| Publication status | Published - Jun 2007 |
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Keywords
- Chemotherapy
- Organ preservation
- Radiotherapy
- Treatment
- Urinary cancers
ASJC Scopus subject areas
- Oncology
- Hematology
- Cancer Research
Cite this
Role of external radiation therapy in urinary cancers. / Parisi, S.; Troiano, M.; Corsa, P.; Raguso, A.; Cossa, S.; Piazzolla, E. E.; Munafò, T.; Sanpaolo, G.; Natuno, A.; Maiello, E.
In: Annals of Oncology, Vol. 18, No. SUPPL. 6, 06.2007.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of external radiation therapy in urinary cancers
AU - Parisi, S.
AU - Troiano, M.
AU - Corsa, P.
AU - Raguso, A.
AU - Cossa, S.
AU - Piazzolla, E. E.
AU - Munafò, T.
AU - Sanpaolo, G.
AU - Natuno, A.
AU - Maiello, E.
PY - 2007/6
Y1 - 2007/6
N2 - Invasive urinary tumors are relatively rare and their treatment may cause important changes in urinary, sexual, and social functions. A systematic review of external radiation therapy studies in urinary cancers has been carried out. This synthesis of the literature is based on data from meta-analysis, randomized and prospective trials, and retrospective studies. There are few controlled clinical trials using adjuvant or radical radiotherapy ± chemotherapy in kidney, ureter, and urethra cancers; there are several reports of muscle-invasive bladder cancer using multimodality treatment: intravesical surgery and neo-adjuvant chemotherapy to radiotherapy or concomitant radiochemotherapy with organ preservation. The conclusions reached for renal cancer are controversial; urethra and ureter cancers data are few and inconclusive; sufficient data now exist in literature to demonstrate that conservative management with organ preservation, for muscle-invasive bladder cancer, is a valid alternative to radical cystectomy, viewed as the gold standard.
AB - Invasive urinary tumors are relatively rare and their treatment may cause important changes in urinary, sexual, and social functions. A systematic review of external radiation therapy studies in urinary cancers has been carried out. This synthesis of the literature is based on data from meta-analysis, randomized and prospective trials, and retrospective studies. There are few controlled clinical trials using adjuvant or radical radiotherapy ± chemotherapy in kidney, ureter, and urethra cancers; there are several reports of muscle-invasive bladder cancer using multimodality treatment: intravesical surgery and neo-adjuvant chemotherapy to radiotherapy or concomitant radiochemotherapy with organ preservation. The conclusions reached for renal cancer are controversial; urethra and ureter cancers data are few and inconclusive; sufficient data now exist in literature to demonstrate that conservative management with organ preservation, for muscle-invasive bladder cancer, is a valid alternative to radical cystectomy, viewed as the gold standard.
KW - Chemotherapy
KW - Organ preservation
KW - Radiotherapy
KW - Treatment
KW - Urinary cancers
UR - http://www.scopus.com/inward/record.url?scp=35748937075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35748937075&partnerID=8YFLogxK
U2 - 10.1093/annonc/mdm247
DO - 10.1093/annonc/mdm247
M3 - Article
C2 - 17591812
AN - SCOPUS:35748937075
VL - 18
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - SUPPL. 6
ER -