Role of external radiation therapy in urinary cancers

S. Parisi, M. Troiano, P. Corsa, A. Raguso, S. Cossa, E. E. Piazzolla, T. Munafò, G. Sanpaolo, A. Natuno, E. Maiello

Research output: Contribution to journalArticlepeer-review

Abstract

Invasive urinary tumors are relatively rare and their treatment may cause important changes in urinary, sexual, and social functions. A systematic review of external radiation therapy studies in urinary cancers has been carried out. This synthesis of the literature is based on data from meta-analysis, randomized and prospective trials, and retrospective studies. There are few controlled clinical trials using adjuvant or radical radiotherapy ± chemotherapy in kidney, ureter, and urethra cancers; there are several reports of muscle-invasive bladder cancer using multimodality treatment: intravesical surgery and neo-adjuvant chemotherapy to radiotherapy or concomitant radiochemotherapy with organ preservation. The conclusions reached for renal cancer are controversial; urethra and ureter cancers data are few and inconclusive; sufficient data now exist in literature to demonstrate that conservative management with organ preservation, for muscle-invasive bladder cancer, is a valid alternative to radical cystectomy, viewed as the gold standard.

Original languageEnglish
JournalAnnals of Oncology
Volume18
Issue numberSUPPL. 6
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Chemotherapy
  • Organ preservation
  • Radiotherapy
  • Treatment
  • Urinary cancers

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Cancer Research

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