Abstract
Invasive urinary tumors are relatively rare and their treatment may cause important changes in urinary, sexual, and social functions. A systematic review of external radiation therapy studies in urinary cancers has been carried out. This synthesis of the literature is based on data from meta-analysis, randomized and prospective trials, and retrospective studies. There are few controlled clinical trials using adjuvant or radical radiotherapy ± chemotherapy in kidney, ureter, and urethra cancers; there are several reports of muscle-invasive bladder cancer using multimodality treatment: intravesical surgery and neo-adjuvant chemotherapy to radiotherapy or concomitant radiochemotherapy with organ preservation. The conclusions reached for renal cancer are controversial; urethra and ureter cancers data are few and inconclusive; sufficient data now exist in literature to demonstrate that conservative management with organ preservation, for muscle-invasive bladder cancer, is a valid alternative to radical cystectomy, viewed as the gold standard.
Original language | English |
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Journal | Annals of Oncology |
Volume | 18 |
Issue number | SUPPL. 6 |
DOIs | |
Publication status | Published - Jun 2007 |
Keywords
- Chemotherapy
- Organ preservation
- Radiotherapy
- Treatment
- Urinary cancers
ASJC Scopus subject areas
- Oncology
- Hematology
- Cancer Research