TY - JOUR
T1 - Role of extracellular vesicles in epithelial ovarian cancer
T2 - A systematic review
AU - Lucidi, Alessandro
AU - Buca, Danilo
AU - Ronsini, Carlo
AU - Tinari, Sara
AU - Bologna, Giuseppina
AU - Buca, Davide
AU - Leombroni, Martina
AU - Liberati, Marco
AU - D’antonio, Francesco
AU - Scambia, Giovanni
AU - Lanuti, Paola
AU - Petrillo, Marco
N1 - Funding Information:
Funding: The authors are grateful for financial support from the “Fondazione Ricerca Fibrosi Cistica-Onlus” (grant code: FFC#29/2018), the “Cystic Fibrosis Foundation (CFF)” (Application #: 622009), and to the “Fondazione Celiachia Onlus” (Grant FC Fellowship_004_2016_Bologna).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/2
Y1 - 2020/11/2
N2 - Extracellular vesicles (EVs) are a heterogeneous group of cell-derived submicron vesicles released under physiological or pathological conditions. EVs mediate the cellular crosstalk, thus contributing to defining the tumor microenvironment, including in epithelial ovarian cancer (EOC). The available literature investigating the role of EVs in EOC has been reviewed following PRISMA guidelines, focusing on the role of EVs in early disease diagnosis, metastatic spread, and the development of chemoresistance in EOC. Data were identified from searches of Medline, Current Contents, PubMed, and from references in relevant articles from 2010 to 1 April 2020. The research yielded 194 results. Of these, a total of 36 papers, 9 reviews, and 27 original types of research were retained and analyzed. The literature findings demonstrate that a panel of EV-derived circulating miRNAs may be useful for early diagnosis of EOC. Furthermore, it appears clear that EVs are involved in mediating two crucial processes for metastatic and chemoresistance development: the epithelial–mesenchymal transition, and tumor escape from the immune system response. Further studies, more focused on in vivo evidence, are urgently needed to clarify the role of EV assessment in the clinical management of EOC patients.
AB - Extracellular vesicles (EVs) are a heterogeneous group of cell-derived submicron vesicles released under physiological or pathological conditions. EVs mediate the cellular crosstalk, thus contributing to defining the tumor microenvironment, including in epithelial ovarian cancer (EOC). The available literature investigating the role of EVs in EOC has been reviewed following PRISMA guidelines, focusing on the role of EVs in early disease diagnosis, metastatic spread, and the development of chemoresistance in EOC. Data were identified from searches of Medline, Current Contents, PubMed, and from references in relevant articles from 2010 to 1 April 2020. The research yielded 194 results. Of these, a total of 36 papers, 9 reviews, and 27 original types of research were retained and analyzed. The literature findings demonstrate that a panel of EV-derived circulating miRNAs may be useful for early diagnosis of EOC. Furthermore, it appears clear that EVs are involved in mediating two crucial processes for metastatic and chemoresistance development: the epithelial–mesenchymal transition, and tumor escape from the immune system response. Further studies, more focused on in vivo evidence, are urgently needed to clarify the role of EV assessment in the clinical management of EOC patients.
KW - Epithelial mesenchymal transition
KW - Extracellular vesicles
KW - Immunological escape
KW - MicroRNAs
KW - Ovarian cancer
KW - Tumor microenvironment
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U2 - 10.3390/ijms21228762
DO - 10.3390/ijms21228762
M3 - Review article
C2 - 33228245
AN - SCOPUS:85096291914
VL - 21
SP - 1
EP - 16
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 22
M1 - 8762
ER -