Role of extracorporeal circulation in adult respiratory distress syndrome management.

L. Gattinoni, A. Pesenti, M. Bombino, P. Pelosi, L. Brazzi

Research output: Contribution to journalArticle

Abstract

Long-term extracorporeal support for acute lung failure was introduced in 1972. In the 1970s, much effort was concentrated on technical improvements. However, a multicenter study comparing continuous positive-pressure ventilation and continuous positive-pressure ventilation plus extracorporeal circulation failed to show improvement in survival rates. In the 1980s, new physiopathologic concepts were developed, such as extracorporeal CO2 removal coupled with lung rest. The main complication of the technique was bleeding due to systemic heparinization. However, the technology used in that period was the same as in the 1970s. Recently, technological improvement--such as percutaneous cannulation and surface-heparinized artificial lungs--has allowed clinical performances to improve substantially. "Lung rest" philosophy, coupled with safe technology, may provide a rational basis to test this technique in a randomized fashion for widespread use.

Original languageEnglish
Pages (from-to)603-612
Number of pages10
JournalNew horizons (Baltimore, Md.)
Volume1
Issue number4
Publication statusPublished - Nov 1993

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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    Gattinoni, L., Pesenti, A., Bombino, M., Pelosi, P., & Brazzi, L. (1993). Role of extracorporeal circulation in adult respiratory distress syndrome management. New horizons (Baltimore, Md.), 1(4), 603-612.