Role of extracorporeal circulation in adult respiratory distress syndrome management.

L. Gattinoni, A. Pesenti, M. Bombino, P. Pelosi, L. Brazzi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Long-term extracorporeal support for acute lung failure was introduced in 1972. In the 1970s, much effort was concentrated on technical improvements. However, a multicenter study comparing continuous positive-pressure ventilation and continuous positive-pressure ventilation plus extracorporeal circulation failed to show improvement in survival rates. In the 1980s, new physiopathologic concepts were developed, such as extracorporeal CO2 removal coupled with lung rest. The main complication of the technique was bleeding due to systemic heparinization. However, the technology used in that period was the same as in the 1970s. Recently, technological improvement--such as percutaneous cannulation and surface-heparinized artificial lungs--has allowed clinical performances to improve substantially. "Lung rest" philosophy, coupled with safe technology, may provide a rational basis to test this technique in a randomized fashion for widespread use.

Original languageEnglish
Pages (from-to)603-612
Number of pages10
JournalNew horizons (Baltimore, Md.)
Volume1
Issue number4
Publication statusPublished - Nov 1993

Fingerprint

Extracorporeal Circulation
Adult Respiratory Distress Syndrome
Lung
Positive-Pressure Respiration
Technology
Catheterization
Multicenter Studies
Hemorrhage

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Gattinoni, L., Pesenti, A., Bombino, M., Pelosi, P., & Brazzi, L. (1993). Role of extracorporeal circulation in adult respiratory distress syndrome management. New horizons (Baltimore, Md.), 1(4), 603-612.

Role of extracorporeal circulation in adult respiratory distress syndrome management. / Gattinoni, L.; Pesenti, A.; Bombino, M.; Pelosi, P.; Brazzi, L.

In: New horizons (Baltimore, Md.), Vol. 1, No. 4, 11.1993, p. 603-612.

Research output: Contribution to journalArticle

Gattinoni, L, Pesenti, A, Bombino, M, Pelosi, P & Brazzi, L 1993, 'Role of extracorporeal circulation in adult respiratory distress syndrome management.', New horizons (Baltimore, Md.), vol. 1, no. 4, pp. 603-612.
Gattinoni L, Pesenti A, Bombino M, Pelosi P, Brazzi L. Role of extracorporeal circulation in adult respiratory distress syndrome management. New horizons (Baltimore, Md.). 1993 Nov;1(4):603-612.
Gattinoni, L. ; Pesenti, A. ; Bombino, M. ; Pelosi, P. ; Brazzi, L. / Role of extracorporeal circulation in adult respiratory distress syndrome management. In: New horizons (Baltimore, Md.). 1993 ; Vol. 1, No. 4. pp. 603-612.
@article{d2574a39def04064bc6863b8f0b25fe0,
title = "Role of extracorporeal circulation in adult respiratory distress syndrome management.",
abstract = "Long-term extracorporeal support for acute lung failure was introduced in 1972. In the 1970s, much effort was concentrated on technical improvements. However, a multicenter study comparing continuous positive-pressure ventilation and continuous positive-pressure ventilation plus extracorporeal circulation failed to show improvement in survival rates. In the 1980s, new physiopathologic concepts were developed, such as extracorporeal CO2 removal coupled with lung rest. The main complication of the technique was bleeding due to systemic heparinization. However, the technology used in that period was the same as in the 1970s. Recently, technological improvement--such as percutaneous cannulation and surface-heparinized artificial lungs--has allowed clinical performances to improve substantially. {"}Lung rest{"} philosophy, coupled with safe technology, may provide a rational basis to test this technique in a randomized fashion for widespread use.",
author = "L. Gattinoni and A. Pesenti and M. Bombino and P. Pelosi and L. Brazzi",
year = "1993",
month = "11",
language = "English",
volume = "1",
pages = "603--612",
journal = "New Horizons: Science and Practice of Acute Medicine",
issn = "1063-7389",
publisher = "Williams & Wilkins Co.",
number = "4",

}

TY - JOUR

T1 - Role of extracorporeal circulation in adult respiratory distress syndrome management.

AU - Gattinoni, L.

AU - Pesenti, A.

AU - Bombino, M.

AU - Pelosi, P.

AU - Brazzi, L.

PY - 1993/11

Y1 - 1993/11

N2 - Long-term extracorporeal support for acute lung failure was introduced in 1972. In the 1970s, much effort was concentrated on technical improvements. However, a multicenter study comparing continuous positive-pressure ventilation and continuous positive-pressure ventilation plus extracorporeal circulation failed to show improvement in survival rates. In the 1980s, new physiopathologic concepts were developed, such as extracorporeal CO2 removal coupled with lung rest. The main complication of the technique was bleeding due to systemic heparinization. However, the technology used in that period was the same as in the 1970s. Recently, technological improvement--such as percutaneous cannulation and surface-heparinized artificial lungs--has allowed clinical performances to improve substantially. "Lung rest" philosophy, coupled with safe technology, may provide a rational basis to test this technique in a randomized fashion for widespread use.

AB - Long-term extracorporeal support for acute lung failure was introduced in 1972. In the 1970s, much effort was concentrated on technical improvements. However, a multicenter study comparing continuous positive-pressure ventilation and continuous positive-pressure ventilation plus extracorporeal circulation failed to show improvement in survival rates. In the 1980s, new physiopathologic concepts were developed, such as extracorporeal CO2 removal coupled with lung rest. The main complication of the technique was bleeding due to systemic heparinization. However, the technology used in that period was the same as in the 1970s. Recently, technological improvement--such as percutaneous cannulation and surface-heparinized artificial lungs--has allowed clinical performances to improve substantially. "Lung rest" philosophy, coupled with safe technology, may provide a rational basis to test this technique in a randomized fashion for widespread use.

UR - http://www.scopus.com/inward/record.url?scp=0027693206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027693206&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 603

EP - 612

JO - New Horizons: Science and Practice of Acute Medicine

JF - New Horizons: Science and Practice of Acute Medicine

SN - 1063-7389

IS - 4

ER -