Role of family history in patients with myocardial infarction: An Italian case-control study

Maria Carla Roncaglioni, Luigi Santoro, Barbara D'Avanzo, Eva Negri, Alessandro Nobili, Antonietta Ledda, Ferdinando Pietropaolo, Maria Grazia Franzosi, Carlo La Vecchia, Giorgio A. Feruglio, Attilio Maseri

Research output: Contribution to journalArticle

Abstract

Background. A family history of heart disease has been reported to increase the risk of coronary heart disease. We examined the relation between family history of myocardial infarction (MI) and risk of acute MI to establish the independency of this association, the degree of risk in relation to the number and age of relatives affected, and the possible interaction between family history and other major risk factors for MI. Methods and Results. In a case-control study conducted in Italy within the framework of the GISSI-2 Trial, 916 cases of newly diagnosed MI and 1,106 hospital controls were identified. Using a structured questionnaire, data were collected on the history of MI in first-degree relatives and the age at which the event occurred. Compared with subjects without family history of MI in first-degree relatives, the relative risk (RR) of MI was 2.0 (95% confidence interval, CI, 1.6-2.5) in those with one and 3.0 (95% CI, 2.0-4.4) in those with two or more relatives affected (χ2 1 test for trend, 54.1; p226 mg/dl led to an RR of 14 (95% CI, 3.7-50.0) and 8.3 (95% CI, 1.8-38.7), respectively. Conclusions. This study indicates that a family history of MI is an independent risk factor for MI, and that the number of relatives and the age at which they were affected is related to the strength of the association. There is a multiplicative effect on RR between family history and several major risk factors for MI.

Original languageEnglish
Pages (from-to)2065-2072
Number of pages8
JournalCirculation
Volume85
Issue number6
Publication statusPublished - Jun 1992

Keywords

  • Case-control studies
  • Family history
  • Myocardial infarction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Roncaglioni, M. C., Santoro, L., D'Avanzo, B., Negri, E., Nobili, A., Ledda, A., Pietropaolo, F., Franzosi, M. G., La Vecchia, C., Feruglio, G. A., & Maseri, A. (1992). Role of family history in patients with myocardial infarction: An Italian case-control study. Circulation, 85(6), 2065-2072.